Shift.ms
Donate
Learn about MS
MS symptoms
MS symptomsA guide to MS symptomsWhat are the early signs of MS?Understanding visible and invisible symptoms of MSMS HugMS and optic neuritis
MS diagnosis
MS diagnosisBeing diagnosed with MSWhat is MS?Different types of MSIs MS hereditary?Late onset MS and treatment
MS treatment
MS treatmentGetting treatment for MSCoping with MS fatigueExercising with MSUnderstanding MS relapseHSCT treatment for MS
Living with MS
Living with MSAfter diagnosis: living with MSMultiple sclerosis and mental healthWorking with MSMS, sex and relationshipsA guide to MS benefits in the UK
  • Forum
  • Learn about MS
  • MS symptoms
  • MS diagnosis
  • MS treatment
  • Living with MS
  • Find MSers
  • Buddy Network
  • Films
  • MS Latest
  • Get Involved
  • Volunteer
  • Fundraise
  • Donate
  • About us
  • Contact us
  • House rules
  • Terms of use
  • Privacy policy
  • Cookie policy
Sign in

We are a charity and rely on donations

Charity Number: 1117194 (England and Wales)

Registered Company: 06000961

Registered address:
Shift.ms, Platform, New Station Street, LS1 4JB, United Kingdom

London office:
Shift.ms, Somerset House, Strand, West Goods Entrance, London WC2R 1LA, United Kingdom

©2025 Shift.ms

Looking for
something specific?

  • Picked for you
  • Browse topics
  • Find MSers

Topics

  • Diagnosis
  • Symptoms
  • Newly diagnosed
  • Healthy living
  • Research
  • Disclosure
  • MRI
  • Browse all
Sort 177 results by
Recent activityNewest posts

@Katejj 

Last reply

Katejj

PML- symptoms

Hi all, Has anyone had PML before? The symptoms are the same as an MS relapse so I’m so scared it’s that after ten years on Tysabri. Thank you.
London, United Kingdom
19

@happysquirrel 

Last reply

happysquirrel

PML concerns

Hello, Does anyone on Ocrevus or Kesimpta worry about developing PML. I've been advised to take one of these but given the risks of PML, which I think is incurable, I'm really worried. The MS nurse didn't seem too concerned but how can we not be?! Is it just me or am I overthinking it? I know it's...
First posted on the Shift.ms app
14

@MSfighterAR 

Last reply

MSfighterAR

Drug no pml cases

Hello I’m on gilenya for years. Symptoms free. But I feel my heart isn’t brave as it used to be lol Anyway I have an appointment with the neurologist on Feb and I don’t want to continue till pml accures with gilenya to be honest I’m afraid what do you suggest I take after I want to take a drug with ...
  • Gilenya
  • Treatment
  • Symptoms
  • Tysabri
  • Diagnosis
3

@Duggles2000 

Last reply

Duggles2000

PML risk

Is PML a risk with all DMT? I'm currently waiting for my Neurologist to review my latest MRI and provide my treatment options but I keep seeing PML mentioned when I read anything and it's making me really anxious about the future. Can anyone give any advice on this?
Wolverhampton, UK
  • Treatment
  • Which DMT
  • MRI
  • Tysabri
  • Symptoms
  • Diagnosis
  • Mental health
9

@Akjoyce1988 

EditedLast reply

Akjoyce1988

MS, Ocrevus and PML.

Hey all. I was officially diagnosed in November 2022, when I landed myself in the hospital (for a 7 month stay due to paralysis from the ribs down) and was started on Ocrevus. Since then I’ve often found myself going down the rabbit hole of being terrified of getting PML and dying. Can you please g...
Hamilton, Ontario, Canada
  • Ocrevus
  • Newly diagnosed
  • Diagnosis
  • Treatment
  • Symptoms
5

@hannahvbanana 

Last reply

hannahvbanana

Fear of PML

I am going into my second Rituxan infusion this week after being diagnosed with MS last May. I can't help but get extremely anxious in the weeks before and the weeks following infusion due to the reminder of the very rare risk of PML. I think I get so anxious because it is so unknown, my neurologist...
Vancouver, Canada
  • Mental health
  • Tysabri
  • Symptoms
  • Newly diagnosed
  • Diagnosis
  • Treatment
  • Ocrevus
  • Relapsing remitting
1

@Alicja 

EditedLast reply

Alicja

KESIMPTA or OCREVUS - PML

Hi, I need some advice on KESIMPTA and OCREVUS. I know they both cause infections, including brain infection PML! Does anyone can say something about those drugs and PML (from experience)? Many Thanks!
  • Ocrevus
  • Treatment
  • Tysabri
  • Fun drugs
  • Work and play
  • MRI
3

@MiaPi 

Last reply

MiaPi

PML risk with OCREVUS or Cladribine

Hi All, I had written a while ago mentioning that I have been recommended to switch from Copaxone to Tecfidera. Well, I decided not to, without first getting a second opinion. I am still waiting for this second opinion apt which apparently is going to take a couple of months.. The reason I decid...
  • Ocrevus
  • Treatment
  • Tecfidera
  • Fun drugs
  • Unlicensed
  • Work and play
  • Tysabri
  • Disclosure
  • Mavenclad
9

@californiadreamin 

Last reply

californiadreamin

Pml treatment

One of the scariest side effects of ms dmts is pml. This article seemed pretty exciting and didn’t seem to make the news much so I thought I would post it here. Given how serious and rare it is not sure what kind of trial would be needed. I hope to find out more because if anyone gets this li...
  • Treatment
  • Which DMT
  • Tysabri
  • Unlicensed
8

@alt258 

Last reply

alt258

Gilenya and PML

My neuro has recommended gilenya, as I have failed rebif. I tested positive for JCV and I'm concerned about the risk of PML. The symptoms of PML are identical to my daily MS symptoms. I understand and that the risk of developing PML is low, but it's really got me concerned and I can't seem to shake ...
  • Relapsing remitting
  • Symptoms
  • Treatment
  • Gilenya
6
PreviousNext page