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Charity Number: 1117194 (England and Wales)

Registered Company: 06000961

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Shift.ms, Platform, New Station Street, LS1 4JB, United Kingdom

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Shift.ms, Somerset House, Strand, West Goods Entrance, London WC2R 1LA, United Kingdom

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@watsoncraig 

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watsoncraig

De-bunk myth

On my Facebook this popped up Every week, around 130 people are diagnosed with MS. Most people have heard of MS, but many don’t realise how it can affect you. We want to change that. This week, we’re launching our #MSUncovered campaign to sort the facts from the myths, show the different faces of M...
  • Diagnosis
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4
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@Tia 

Last reply

Tia

Saw this and wanted to share : A microscopic discovery may quietly change how multiple sclerosis drugs are designed and why their side effects happen at all.For years, doctors have relied on immune-modulating drugs to slow multiple sclerosis (MS), even though many come with troubling side effects affecting the heart, lungs, or nervous system. Now, scientists from Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center have uncovered why some of those side effects occur and how future drugs could avoid them.Using ultra-high-resolution cryo-electron microscopy, researchers mapped the exact molecular structure of siponimod, a next-generation MS drug, as it binds to its immune target: the S1P1 receptor. This receptor acts like a gatekeeper, controlling whether aggressive immune cells escape lymph nodes and attack nerve insulation in the brain and spinal cord.The breakthrough? Scientists discovered precisely which parts of the drug help it hit the right receptor and which subtle features cause it to accidentally bind to similar receptors linked to abnormal heart rhythms and other side effects. With this structural “blueprint,” future MS drugs could be engineered to lock onto the correct target more tightly while avoiding the rest.Even more intriguing, the study reveals how nearly identical natural lipids can behave completely differently inside the body, shaping immune, brain, and lung function. That insight may ripple beyond MS, influencing treatments for lupus, psoriasis, inflammatory bowel disease and even lung disease.If medicines could be redesigned at the molecular level to spare the rest of the body, would you accept stronger immune control with fewer side effects?

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5

@Craig2000 

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Craig2000

Neck discomfort advice - what do you think?

SPMSer for a couple of years now, with standard MS issues, balance, fatigue, bladder the size of a walnut etc etc. For about 4 weeks now i've had what feels like muscle discomfort in the back of my neck, right rear side, as if i've slept uncovered and caught a cold breeze across it. I have done that...
  • Symptoms
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3

@DominicS 

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DominicS

Covid-19 - Next Steps. Don't Touch Me!

Now we have officially moved to the Delay phase in the UK an additional thing to think about is Social Distancing. - Many, especially people who don't know is in the UK, think we are masters at this already. - Nonetheless, this is simply about physical distance. Touching, hugging, holding hands, kis...
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