Hello all, I'd like some thoughts from you knowledgable folk plz. I was diagnosed rrms in September 2017 and have been on tec since March 2019. I have remained stable, however my most recent MRI last month (delayed from March) has shown 4 new areas of inflammation. I have not had a noticable relapse, although fatigue is definitely worse, and old symptoms I experienced have reappeared. Wet, heavy legs (sensory, not bladder problems) and heavy, prickly arms, the most noticable. My neuro is suggesting this happened before the tec became effective. This would be before September 2019. I am certain these new symptoms have been with me only since the early part of this year, but my neuro gives the dmt's credit for everything positive and doesn't hear anything different! So, thinking about what else has changed for me, I was taking sildenafil regularly until November last year. Unfortunately sex is a just lovely memory for me at the moment. I have lost all interest and my partner has her own health problems too. So, this set my mind working, wondering if there could be any connection.... and lo and behold, a 2013 trial by barts showed a positive relation between ms and sildenafil. I can't find any further studies and can't believe after such positive result this was not studied further. Has anyone else had a similar experience, either improvement after taking sildenafil, or decline after stopping it? Has anyone seen any further studies on this? Also, does the fact I have not had a noticable relapse, just a worsening of previous, could I now be secondary progressive? Thanks all Matt