#sideeffects - Shift.ms

@hmza92

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Plegridy side effects as well as a cold

Does anyone have this experience. Because I am currently going through it and it is Plegridy side effects x100!

Bradford, United Kingdom

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2

@ShawtyL54

Hi, MS Warriors, I've noticed I'm more fatigue & it slows me down physically & mentally. I've tried 2 different type of meds. but I had side effects so my doctor told me to stop taking it. That been over 3/4 yrs. ago (can't remember what meds. they were🤔)Anyhoo, can anyone help me? I take vitamins & don't want to take more pills. I want to start back walking that helped give me some energy but right now I'm too fatigue. So, do anyone know what can help?

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@PumaPie

NIHNational Institutes of HealthTurning Discovery Into HealthMENU< News & EventsMarch 27, 2018Gut microbe drives autoimmunityAt a Glance• Scientists found evidence that a certain gut microbe can trigger autoimmune disease in mice that are prone to such disease and identified the same microbe inpeople with autoimmune diseases.• The results suggest new avenues At a Glance• Scientists found evidence that a certain gut microbe can trigger autoimmune disease in mice thatare prone to such disease and identified the same microbe inpeople with autoimmune diseases.• The results suggest new avenues for treating debilitating and potentially lethal autoimmune diseases. The bacterium E. gallinarum (shown in orange) was found in liver tissue.Martin Kriegel lab, YaleThe human gut harbors a complex community of microbes that affect many aspects of our health. Known as the gut microbiota, these bacteria help with metabolism and maintaining a healthy immune system.The lining of the intestine forms a barrier that is crucial to containing gut microbes. If the lining is breached and a gut microbe is able to get into the bloodstream and nearby organs, it can cause disease. Despite the fact that the body has many ways to prevent the breach, microbes sometimes get through.Previous studies have linked certain gut microbes to autoimmune disease, in which the immune system mistakenly attacks the body's own tissues. A team led by Dr. Martin Kriegel at Yale investigated whether microbes breaching the gut barrier were involved in autoimmune disease. Their study was funded in part by NIH's National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Diabetes. and National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).Results appeared in Science on March 9, 2018.The researchers first tested how mice predisposed to autoimmune disease were affected by antibiotic treatment. In untreated mice, they found bacteria in nearby lymph nodes and the liver at 16 weeks of age, and also in the spleen 2 weeks later. Mice treated with the antibiotics vancomycin or ampicillin had this deadly growth suppressed.Analysis of cultures from nearby lymph nodes, liver, and spleen revealed the presence of a bacterium called Enterococcus gallinarum.When germ-free mice were colonized by E. gallinarum, the bacteria disrupted the gut barrier, moved into the lymph nodes and liver, and triggered an autoimmune response.To test whether depleting E. gallinarum alone could blunt autoimmune responses, the team developed vaccines using heat-killed bacteria.Vaccinating the prone mice against E. gallinarum, but not against two other gu microbes, reduced autoimmune responses6:30 Mspecific treatment can halt autoimmune responses without suppressing the entire immune system, which can have serious side effects.Finally, the researchers examined liver biopsies from people with autoimmune diseases. They found E. gallinarum in liver biopsies from three people with systemic lupus erythematosus, an autoimmune disease that can damage tissues all over the body. Similarly, the scientists foundE. gallinarum in liver biopsies from most people tested who had autoimmune liver disease.Biopsies from healthy liver transplant donors did not have the microbe.Taken together, these findings show that, in those who are prone, E. gallinarum can move through the gut barrier and into other organs to drive autoimmune responses. The resultssuggest new approaches to developing therapies for autoimmune diseases."The vaccine against E. gallinarum was a specific approach, as vaccinations against other bacteria we investigated did not pre mortality and autoimmunity," Kriegel saysapproaches such as vaccination are promising ways to improve the lives of patients with autoimmune disease."- by Harrison Wein, Ph.D.Related Links• Blocking Stomach Acid May PromoteChronic Liver Disease• Changing Gut Bacteria in Crohn's Disease• Infant Gut Microbes Linked to Allergy, Asthma Risk• Food Additives Alter Gut Microbes, Cause Diseases in Mice• Diet Affects Autoinflammatory Disease ViaGut Microbes• Gut Microbes Linked to RheumatoidArthritis• Your Microbes and You: The Good, Bad

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@Mikeontheroad

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Drugs Side effects worse than MS symptoms

Has anyone experienced side effects with the BCell depleters that were worse than the original MS symptoms? Definitely a question I ask myself as I haven’t started the meds yet and have hardly any symptoms.

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8

@Martin600

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Ocrevus infusion side effects

Hi I have been on Ocrevus for maybe 4 years now and I think it is helping to keep my MS at bay. I also have had very few side effects . Certainly once my infusion is completed it’s all good. I just had my latest infusion which seemed to have a new side effect. For about 3 days following the infusion...

Kemnay, United Kingdom

11

@amandalynn96

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Has anyone been on Tecfidera? Is it any good? Any major side effects? How do you feel after taking? I’m all out of options thanks to insurance not wanting to pay for Ocrevus or Briumvi.

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48

@Zara34

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Hi, today I was diagnosed with MS. I had numbness in hands, arms and feets. I changed to healthy diet and numbness in feets went away.I still have symptoms in hands. I am due to be seen by a neurological doctor. I would like to hear from others how they manage daily life with MS? What treatment are you on and are there any side effects of the medication?

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7

Deleted

@Knuckles1980

Kesimpta side effects

Does anyone else have the feeling that they've broken their feet or ankles for a few days. Normally happens a week after my kesimpta injection. It goes after about 5 days. At first I didn't know why I felt like it. But after 6 months in kesimpta and the same thing happening every month it's just str...

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@viva13

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I recently stopped taking Ocrevus because of the side effects. I was suffering from chronic upper respiratory infections which lead to an ig2 subclass deficiency that requires a monthly antibody infusion which I refused,if that wasn’t enough I was then had to go to have a bone marrow biopsy so now I have MGUS all of which I have to be monitored every 3 to 6 months! I’m sorry my question is has anyone else experienced issues with Ocrevus ? If so did you try another medication?

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2

@n_bushell

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Ocrevus side effects.......

Morning all I had my infusion yesterday, woke up this morning and my face is bright red and hot to touch, this happen to me after the last one in December too 🤔 has anyone else experienced this side effect?? The nurse has told ne to keep taking antihistamines, thinking of trying the subcut in Decem...

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2

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