#cause - Shift.ms

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We are a charity and rely on donations

Charity Number: 1117194 (England and Wales)

Registered Company: 06000961

Registered address:
Shift.ms, Platform, New Station Street, LS1 4JB, United Kingdom

London office:
Shift.ms, Somerset House, Strand, West Goods Entrance, London WC2R 1LA, United Kingdom

©2026 Shift.ms

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Fatigue causes

Does anyone else feel like mental exertion effects fatigue more than physical? I go to the gym & I’m usually fine but if I sit down & have to do my taxes I’m going to be in bed the rest of the day.

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Im a RRMSer, who's recently been diagnosed as a diabetic T1. The symptoms are very much similar fatigue and balance problems. I haven't had a relapse for over 15 years. How do I know what causes my fatigue. Is it my MS or diabetes.

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Cause of MS

https://www.facebook.com/share/p/1Cgn6V42CG/

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Mercury tooth fillings and MS. Curious of finding a cause

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Ocrevus, does it cause bad stomach side effects?

I have been told I can pick briumvi, ocrevus or kesimpta but I think I’m leaning towards the first two because honestly giving myself injections sounds terrifying. I’ve heard ocrevus has more of a chance of causing gastrointestinal issues compared to briumvi and I was just wondering if that is true ...

Gateshead, United Kingdom

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MS cause

https://www.facebook.com/share/p/1CRsp9pBJ8/

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MS's root cause

Something doesn't make any sense to me. To call our bodies stupid because all of the sudden attacks itself is ludicrous. Our bodies are incredibly sophisticated machines and to simply call it "auto" immune disease is completely and falsely wrong. What other conditions occurred because our body was w...

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Saw this and wanted to share : A microscopic discovery may quietly change how multiple sclerosis drugs are designed and why their side effects happen at all.For years, doctors have relied on immune-modulating drugs to slow multiple sclerosis (MS), even though many come with troubling side effects affecting the heart, lungs, or nervous system. Now, scientists from Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center have uncovered why some of those side effects occur and how future drugs could avoid them.Using ultra-high-resolution cryo-electron microscopy, researchers mapped the exact molecular structure of siponimod, a next-generation MS drug, as it binds to its immune target: the S1P1 receptor. This receptor acts like a gatekeeper, controlling whether aggressive immune cells escape lymph nodes and attack nerve insulation in the brain and spinal cord.The breakthrough? Scientists discovered precisely which parts of the drug help it hit the right receptor and which subtle features cause it to accidentally bind to similar receptors linked to abnormal heart rhythms and other side effects. With this structural “blueprint,” future MS drugs could be engineered to lock onto the correct target more tightly while avoiding the rest.Even more intriguing, the study reveals how nearly identical natural lipids can behave completely differently inside the body, shaping immune, brain, and lung function. That insight may ripple beyond MS, influencing treatments for lupus, psoriasis, inflammatory bowel disease and even lung disease.If medicines could be redesigned at the molecular level to spare the rest of the body, would you accept stronger immune control with fewer side effects?

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My neurologist asked if wanted infusion but I refused the side effects and high risk of developing cancer im afraid if it progresses but right now im stable i get an mri next month I just hope and pray I don't have any more lesions I have one I hope that its not more when I go back cause if it is I don't know what to do I've have steroid through iv in the hospital for 5 days broke out in a bad rash I hate side effects

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Well im back in the hospital my lymph is a 3 a I’m in isolation now cause my immune system is not strong enough to fight off a common cold. #MSREALLYSUCKS!

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