#cause - Shift.ms

@Thia84

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Anyone else diagnosed with Spinal MS? I had never heard of it until I was diagnosed a year ago. I have cists from my C1 to C7 of my spine. Causes paralysis on my right side and severe nerve pain that is like seering burning needle like pain in my left. My eyes, hearing and memory has been greatly affected too.

Whittier, United States

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@PumaPie

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NIHNational Institutes of HealthTurning Discovery Into HealthMENU< News & EventsMarch 27, 2018Gut microbe drives autoimmunityAt a Glance• Scientists found evidence that a certain gut microbe can trigger autoimmune disease in mice that are prone to such disease and identified the same microbe inpeople with autoimmune diseases.• The results suggest new avenues. At a Glance• Scientists found evidence that a certain gut microbe can trigger autoimmune disease in mice thatare prone to such disease and identified the same microbe inpeople with autoimmune diseases.• The results suggest new avenues for treating debilitating and potentially lethal autoimmune diseases. The lining of the intestine forms a barrier that is crucial to containing gut microbes. If the lining is breached and a gut microbe is able to get into the bloodstream and nearby organs, it can cause disease. Despite the fact that the body has many ways to prevent the breach, microbes sometimes get through.Previous studies have linked certain gut microbes to autoimmune disease, in which the immune system mistakenly attacks the body's own tissues.

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3

@RuthM56

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DOES ANYONE HAVE PAIN IN BACK OF HEAD TO CAUSE UNSTEADY BALANCE?

HI ALL MS FRIENDS LATELY I BEEN HAVING PAIN IN BACK OF HEAD THAT IS CAUSING UNSTEADY BALANCE PROBLEMS AND NEED ADVICE OF WHAT KIND OF MOBILITY DEVICE I NEED

Toledo, United States

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1

@PumaPie

3:14•NEWSHEALTH & MEDICINEFinding immune cells that stop a body from attacking itself wins medicine NobelThe 2025 prize goes to 3 researchers who ID'd T-regs and their role in autoimmune diseaseMary Brunkow (left), Fred Ramsdell (middle) and Shimon Sakaguchi (right) have won the Nobel Prize in physiology or medicine for discovering regulatory T cells, which keep the immune system from attacking the body.NIKLAS ELMEHED © NOBEL PRIZE OUTREACH 3:15Work on peacemakers in the immune system won the 2025 Nobel Prize in physiology or medicine.The peacemakers are regulatory T cells, a type of immune cell that calms the immune system after it has finished fighting infection or healing a wound.These special T cells also prevent the immune system from attacking the body. If they fail in this mission, autoimmune disorders or damaging inflammation can result. These cells are also important to prevent rejection of the fetus during pregnancy.3:15•Shimon Sakaguchi of Osaka University in Japan first discovered these important cells, also known as T-regs, in 1995. Sakaguchi shares the prize, worth 11 million Swedish kronor (over $1.1 million), with Mary Brunkow of the Institute for Systems Biology in Seattle and Fred Ramsdell, a cofounder of Sonoma Biotherapeutics, a company based in San Francisco and Seattle. The Nobel Assembly at the Karolinska Institute in Stockholm announced the prize October 6.Brunkow and Ramsdell tracked down a mutation that caused a fatal autoimmune disease in male mouse pups while working at Celltech Chiroscience in Bothell, Wash., in the 1990s. The mutation turned out to disable a gene called FOXP3. That gene is important for T-reg development, Sakaguchi later discovered. Without it, there aren't enough T-regs to stop 3:15のthere aren't enough T-regs to stop wayward immune cells from causing harm in the body. Mutations in FOXP3 are also responsible for an autoimmune disease called IPEX in people, the American duo revealed in 2001.Scientists are learning to harness T-regs to prevent rejection of transplanted organs and treat autoimmune disorders, food allergies, cancer and other conditions in which the immune system is overactive or directed against the wrong thing.Questions or comments on this article? E-mail usat [email protected]/

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Unpublished

@PumaPie

Finding immune cells that stop a body from attacking itself wins medicine NobelThe 2025 prize goes to 3 researchers who ID'd T-regs and their role in autoimmune diseaseMary Brunkow (left), Fred Ramsdell (middle) and Shimon Sakaguchi (right) have won the Nobel Prize in physiology or medicine for discovering regulatory T cells, which keep the immune system from attacking the body.NIKLAS ELMEHED © NOBEL PRIZE 3:15Work on peacemakers in the immune system won the 2025 Nobel Prize in physiology or medicine.The peacemakers are regulatory T cells, a type of immune cell that calms the immune system after it has finished fighting infection or healing a wound.These special T cells also prevent the immune system from attacking the body. If they fail in this mission, autoimmune disorders or damaging inflammation can result. These cells are also important to prevent rejection of the fetus during pregnancy.3:15•Shimon Sakaguchi of Osaka University in Japan first discovered these important cells, also known as T-regs, in 1995. Sakaguchi shares the prize, worth 11 million Swedish kronor (over $1.1 million), with Mary Brunkow of the Institute for Systems Biology in Seattle and Fred Ramsdell, a cofounder of Sonoma Biotherapeutics, a company based in San Francisco and Seattle. The Nobel Assembly at the Karolinska Institute in Stockholm announced the prize October 6.Brunkow and Ramsdell tracked down a mutation that caused a fatal autoimmune disease in male mouse pups while working at Celltech Chiroscience in Bothell, Wash., in the 1990s. The mutation turned out to disable a gene called FOXP3. That gene is important for T-reg development, Sakaguchi later discovered. Without it, there aren't enough T-regs to stop wayward immune cells from causing 3:15のthere aren't enough T-regs to stop wayward immune cells from causing harm in the body. Mutations in FOXP3 are also responsible for an autoimmune disease called IPEX in people, the American duo revealed in 2001.Scientists are learning to harness T-regs to prevent rejection of transplanted organs and treat autoimmune disorders, food allergies, cancer and other conditions in which the immune system is overactive or directed against the wrong thing.Questions or comments on this article? E-mail usat [email protected]/

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@AcSantos

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Can anyone help me,I don’t have insurance so I haven’t been able to receive treatment and I’m mentally getting worse ,I’m trying to get a program but my neurologist won’t answer after a month of calling I just need help so I can stop being a burden and get a job and stop living off my mom cause she doesn’t have anything as it is

Tavares, United States

First posted on the Shift.ms app

21

@PumaPie

Good news for us all. Finding immune cells that stop a body from attacking itself wins medicine NobelThe 2025 prize goes to 3 researchers who ID'd T-regs and their role in autoimmune diseaseMary Brunkow (left), Fred Ramsdell (middle) and Shimon Sakaguchi (right) have won the Nobel Prize in physiology or medicine for discovering regulatory T cells, which keep the immune system from attacking the body.NIKLAS ELMEHED © NOBEL PRIZE OUTREACHYou have three complimentary articles left Work on peacemakers in the immune system won the 2025 Nobel Prize in physiology or medicine.The peacemakers are regulatory T cells, a type of immune cell that calms the immune system after it has finished fighting infection or healing a wound.These special T cells also prevent the immune system from attacking the body. If they fail in this mission, autoimmune disorders or damaging inflammation can result. These cells are also important to prevent rejection of the fetus during pregnancy. Shimon Sakaguchi of Osaka University in Japan first discovered these important cells, also known as T-regs, in 1995. Sakaguchi shares the prize, worth 11 million Swedish kronor (over $1.1 million), with Mary Brunkow of the Institute for Systems Biology in Seattle and Fred Ramsdell, a cofounder of Sonoma Biotherapeutics, a company based in San Francisco and Seattle. The Nobel Assembly at the Karolinska Institute in Stockholm announced the prize October 6.Brunkow and Ramsdell tracked down a mutation that caused a fatal autoimmune disease in male mouse pups while working at Celltech Chiroscience in Bothell, Wash., in the 1990s. The mutation turned out to disable a gene called FOXP3. That gene is important for T-reg development, Sakaguchi later discovered. Without it, wayward immune cells from causing harm in the body. Mutations in FOXP3 are also responsible for an autoimmune disease called IPEX in people, the American duo revealed in 2001.Scientists are learning to harness T-regs to prevent rejection of transplanted organs and treat autoimmune disorders, food allergies, cancer and other conditions in which the immune system is overactive or directed against the wrong thing.Questions or comments on this article? E-mail usat [email protected]/. Sorry if this is not continuous but I was copying and pasting the article to try to showcase it.

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@PumaPie

approaches such as vaccination are promising ways to improve the lives of patients with autoimmune disease."- by Harrison Wein, Ph.D.Related Links• Blocking Stomach Acid May PromoteChronic Liver Disease• Changing Gut Bacteria in Crohn's Disease• Infant Gut Microbes Linked to Allergy, Asthma Risk• Food Additives Alter Gut Microbes, Cause Diseases in Mice• Diet Affects Autoinflammatory Disease ViaGut Microbes• Gut Microbes Linked to RheumatoidArthritis• Your Microbes and You: The Good, Bad

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@PumaPie

NIHNational Institutes of HealthTurning Discovery Into HealthMENU< News & EventsMarch 27, 2018Gut microbe drives autoimmunityAt a Glance• Scientists found evidence that a certain gut microbe can trigger autoimmune disease in mice that are prone to such disease and identified the same microbe inpeople with autoimmune diseases.• The results suggest new avenues At a Glance• Scientists found evidence that a certain gut microbe can trigger autoimmune disease in mice thatare prone to such disease and identified the same microbe inpeople with autoimmune diseases.• The results suggest new avenues for treating debilitating and potentially lethal autoimmune diseases. The bacterium E. gallinarum (shown in orange) was found in liver tissue.Martin Kriegel lab, YaleThe human gut harbors a complex community of microbes that affect many aspects of our health. Known as the gut microbiota, these bacteria help with metabolism and maintaining a healthy immune system.The lining of the intestine forms a barrier that is crucial to containing gut microbes. If the lining is breached and a gut microbe is able to get into the bloodstream and nearby organs, it can cause disease. Despite the fact that the body has many ways to prevent the breach, microbes sometimes get through.Previous studies have linked certain gut microbes to autoimmune disease, in which the immune system mistakenly attacks the body's own tissues. A team led by Dr. Martin Kriegel at Yale investigated whether microbes breaching the gut barrier were involved in autoimmune disease. Their study was funded in part by NIH's National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Diabetes. and National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).Results appeared in Science on March 9, 2018.The researchers first tested how mice predisposed to autoimmune disease were affected by antibiotic treatment. In untreated mice, they found bacteria in nearby lymph nodes and the liver at 16 weeks of age, and also in the spleen 2 weeks later. Mice treated with the antibiotics vancomycin or ampicillin had this deadly growth suppressed.Analysis of cultures from nearby lymph nodes, liver, and spleen revealed the presence of a bacterium called Enterococcus gallinarum.When germ-free mice were colonized by E. gallinarum, the bacteria disrupted the gut barrier, moved into the lymph nodes and liver, and triggered an autoimmune response.To test whether depleting E. gallinarum alone could blunt autoimmune responses, the team developed vaccines using heat-killed bacteria.Vaccinating the prone mice against E. gallinarum, but not against two other gu microbes, reduced autoimmune responses6:30 Mspecific treatment can halt autoimmune responses without suppressing the entire immune system, which can have serious side effects.Finally, the researchers examined liver biopsies from people with autoimmune diseases. They found E. gallinarum in liver biopsies from three people with systemic lupus erythematosus, an autoimmune disease that can damage tissues all over the body. Similarly, the scientists foundE. gallinarum in liver biopsies from most people tested who had autoimmune liver disease.Biopsies from healthy liver transplant donors did not have the microbe.Taken together, these findings show that, in those who are prone, E. gallinarum can move through the gut barrier and into other organs to drive autoimmune responses. The resultssuggest new approaches to developing therapies for autoimmune diseases."The vaccine against E. gallinarum was a specific approach, as vaccinations against other bacteria we investigated did not pre mortality and autoimmunity," Kriegel saysapproaches such as vaccination are promising ways to improve the lives of patients with autoimmune disease."- by Harrison Wein, Ph.D.Related Links• Blocking Stomach Acid May PromoteChronic Liver Disease• Changing Gut Bacteria in Crohn's Disease• Infant Gut Microbes Linked to Allergy, Asthma Risk• Food Additives Alter Gut Microbes, Cause Diseases in Mice• Diet Affects Autoinflammatory Disease ViaGut Microbes• Gut Microbes Linked to RheumatoidArthritis• Your Microbes and You: The Good, Bad

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@CdbFrance

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PPMS since 2011. On ocrevus in 2022. Cancer 2025. Cause by ocrevus? High possibility. Feedback ?

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