Hi Eve, I’m on kesimpta for just over a year. No new symptoms that I know of. Hoping for nothing new on the mri in December. The loading month for kesimpta was fairly rough for me as my body adjusted to it. I’ve heard of other people that had bad months and others who were only affected by first two doses. I take it once a month. The injection itself is easy to take, in a prepared pen. I find the two days after my injection I suffer with some headaches, joint pain and fatigue. But it does lift after that. I haven’t had many illnesses or infections since taking kesimpta (one virus and one covid bout - both which took a little longer to shift than normal) and I work in a school with lots of bugs floating around so the immunosuppressant element has not been as bad as I expected. Hope this helps. Good luck with your decision.

Hi, I'm on Kesimpta. As far as I could tell, Ocrevus and Kesimpta were pretty similar. But Kesimpta had the massive advantage of being an injection I could do at home. That avoids all the hassle of appointments, travel, the time it would take... It's a shame you have to come off Tysabri - sorry about the JCV. But at least you had 2 years - perhaps the good effects will linger on. And you definitely don't want PML! As for the efficacy of Kesimpta, I'm only 6 months in and I don't think my MS was very active (I'm much older...). But I've not had any relapses, just the usual annoying transient paresthesia I get all the time anyway. And I've had no side effects except for the flu like, "post vaccine" like symptoms after first dose or two (MS nurse gave me great advice to take paracetamol 2 hours after the first dose - blunts the side effects). I've had the odd cold - but that was when I was travelling internationally several times a week. On the breast cancer risk, I think I read that the original Ocrevus trial did suggest there might be an increased risk of breast cancer, BUT when they looked at evidence over a longer period the risk was no higher than for the rest of the population. That said, for any of us on immune-modulating drugs, I think it's a good idea to have some schedule in place to check your breasts and trot along to the GP if you find a (almost certainly benign) lump. In fact, all women should really be doing that!