#no - Shift.ms

Forum

We are a charity and rely on donations

Charity Number: 1117194 (England and Wales)

Registered Company: 06000961

Registered address:
Shift.ms, Platform, New Station Street, LS1 4JB, United Kingdom

London office:
Shift.ms, Somerset House, Strand, West Goods Entrance, London WC2R 1LA, United Kingdom

©2025 Shift.ms

Sort approximately 19087 results by

No

First posted on the Shift.ms app

NIHNational Institutes of HealthTurning Discovery Into HealthMENU< News & EventsMarch 27, 2018Gut microbe drives autoimmunityAt a Glance• Scientists found evidence that a certain gut microbe can trigger autoimmune disease in mice that are prone to such disease and identified the same microbe inpeople with autoimmune diseases.• The results suggest new avenues At a Glance• Scientists found evidence that a certain gut microbe can trigger autoimmune disease in mice thatare prone to such disease and identified the same microbe inpeople with autoimmune diseases.• The results suggest new avenues for treating debilitating and potentially lethal autoimmune diseases. The bacterium E. gallinarum (shown in orange) was found in liver tissue.Martin Kriegel lab, YaleThe human gut harbors a complex community of microbes that affect many aspects of our health. Known as the gut microbiota, these bacteria help with metabolism and maintaining a healthy immune system.The lining of the intestine forms a barrier that is crucial to containing gut microbes. If the lining is breached and a gut microbe is able to get into the bloodstream and nearby organs, it can cause disease. Despite the fact that the body has many ways to prevent the breach, microbes sometimes get through.Previous studies have linked certain gut microbes to autoimmune disease, in which the immune system mistakenly attacks the body's own tissues. A team led by Dr. Martin Kriegel at Yale investigated whether microbes breaching the gut barrier were involved in autoimmune disease. Their study was funded in part by NIH's National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Diabetes. and National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).Results appeared in Science on March 9, 2018.The researchers first tested how mice predisposed to autoimmune disease were affected by antibiotic treatment. In untreated mice, they found bacteria in nearby lymph nodes and the liver at 16 weeks of age, and also in the spleen 2 weeks later. Mice treated with the antibiotics vancomycin or ampicillin had this deadly growth suppressed.Analysis of cultures from nearby lymph nodes, liver, and spleen revealed the presence of a bacterium called Enterococcus gallinarum.When germ-free mice were colonized by E. gallinarum, the bacteria disrupted the gut barrier, moved into the lymph nodes and liver, and triggered an autoimmune response.To test whether depleting E. gallinarum alone could blunt autoimmune responses, the team developed vaccines using heat-killed bacteria.Vaccinating the prone mice against E. gallinarum, but not against two other gu microbes, reduced autoimmune responses6:30 Mspecific treatment can halt autoimmune responses without suppressing the entire immune system, which can have serious side effects.Finally, the researchers examined liver biopsies from people with autoimmune diseases. They found E. gallinarum in liver biopsies from three people with systemic lupus erythematosus, an autoimmune disease that can damage tissues all over the body. Similarly, the scientists foundE. gallinarum in liver biopsies from most people tested who had autoimmune liver disease.Biopsies from healthy liver transplant donors did not have the microbe.Taken together, these findings show that, in those who are prone, E. gallinarum can move through the gut barrier and into other organs to drive autoimmune responses. The resultssuggest new approaches to developing therapies for autoimmune diseases."The vaccine against E. gallinarum was a specific approach, as vaccinations against other bacteria we investigated did not pre mortality and autoimmunity," Kriegel saysapproaches such as vaccination are promising ways to improve the lives of patients with autoimmune disease."- by Harrison Wein, Ph.D.Related Links• Blocking Stomach Acid May PromoteChronic Liver Disease• Changing Gut Bacteria in Crohn's Disease• Infant Gut Microbes Linked to Allergy, Asthma Risk• Food Additives Alter Gut Microbes, Cause Diseases in Mice• Diet Affects Autoinflammatory Disease ViaGut Microbes• Gut Microbes Linked to RheumatoidArthritis• Your Microbes and You: The Good, Bad

First posted on the Shift.ms app

EditedLast reply

Are any of you're caregivers irritating? Like in don't understand MS, ask what's wrong or fail to follow a schedule oor any type of direction? Does a caregiver not question this or that and phrase something in a way to make the client feels like dumb or the caregiver giving unsolicited advice or opinions that aren't even asked by the client? Hope these questions make sense if not I'll clarify further.

First posted on the Shift.ms app

Last reply

I found this on social media, unknown author. It was like the words were pulled directly from my mind, I’m sure I’m not alone. I hope our peace will come soon.

Sometimes I wonder what it feels like to live instead of just survive. To wake up and not already feel behind. To breathe without the pressure of yesterday. To exist without the constant fear of what might go wrong. I don’t want a perfect life. I just want a break from survival mode — a day where li...

First posted on the Shift.ms app

Last reply

New insurance won’t pay for MS meds. Guess I’m going to be rawdogging MS from now on. Anyone stopped taking meds? How are you doing? Things the same? Better? Worse?

First posted on the Shift.ms app

EditedLast reply

Has anyone had a mild allergic reaction to the Tysabri injections? It was injection day number 3 today, at noon. I've definitely develped some tongue swelling as the day has gone on. Coincidence? I'm just wondering 🤔. I'm sensible and know what to do if I'm aware of things getting serious etc. I'm posting to see if anyone has a shared experience? My first 2 months were plain sailing ⛵️ ☺️.

First posted on the Shift.ms app

Last reply

Cannot get to my remaining 8 doctors appointments bc Medicare and Medicaid doesn't want to pay for the Ubers. Im homeless, have lost my food stamps, and now cannot get to my doctors and I cannot afford transportation.

Newark, United States

First posted on the Shift.ms app

Last reply

I’ve had RMS for about 26 yrs now. It’s beginning to get difficult doing everyday things, like going to work. What was the sign that told you it was time to stop working? The thought of this terrifies me.

First posted on the Shift.ms app

Last reply

I'm not on any meds as yet. Putting off speaking with the neurologist.

First posted on the Shift.ms app

Last reply

Some days I’m ok other days it’s super hard. I can never count on consistency with my person but I guess at least I know why now. It was much harder when I didn’t know why I had to chose to eat out lay down. Why I couldn’t have the kind of energy my coworkers had and why by the end of a work week I could do nothing but stay in bed and not move till it started over on Monday again. I get really frustrated sometimes but I do try to have some love for myself when I feel this way.

First posted on the Shift.ms app