I took plegridy for about 3 years, and the flu-like symptoms never abated. I switched to Tecfidera, which gave me headaches like migraine headaches for a couple of hours after each dose. I only lasted 6 weeks. Now I've switched to Ponvory which, so far, after 2 months is golden. I can't detect any bad side effects, so I can get on with an exercise schedule for the first time in years, without having to plan around my drugs. Who knows whether it's working? - I haven't had a relapse for a while anyway, but Ponvory at least doesn't have have side effects for me and enables me to get on with living more.