I Have been on Ocrevus for almost two years and throughout this treatment I have never felt better! The only thing I did notice was that I would start to feel sluggish in the lead up to the next infusion. I am currently recovering from a horrible relapse, for which I spent over a week as an inpatient in the hospital. When I presented to my neurologist with left arm weakness and excruciating pain in my head and neck, she said that relapses on ocrevus were very “rare”. I was subsequently admitted to hospital for iv steroids and MRI was booked. MRI showed no new brain lesions (in fact some were less apparent which was brilliant). MRI c-spine showed a new lesion at C5 and there were new lesions on T-spine at T3/T4/T5. All of these lesions were new when compared to last MRI only 5 months ago. I have two questions: 1) Has anyone else relapsed or had progression whilst on ocrelizumab? 2) What options do I have for a next line of treatment? Referral for a BMT was briefly discussed and I really do not know a lot about this as I never considered the fact that I might one day need it. I am due for review with my neurologist soon to discuss all of the above but I am just wondering if there are others in a similar situation?