Hi there all I am currently going through the process of switching from Tysabri to Ocrevus (starts in just under 2 weeks) I have been on Tysabri since April but tested strongly positive for the JC virus, hence the switch of DMT When i was originally comparing the options my nuerologist suggested i naively thought that any treatment which isnt Tysabri has a very minimal/no risk of PML even when JC positive, so when i tested positive i thought "thats fine i just change to something else and that risk is gone" Now i know and understand more and understand it is still a higher risk than i would ideally like.. I find myself every now and again researching and going down the rabbit hole of PML and the risks associated with Ocrevus/most available DMT's And it is a tought pill to swallow I was wondering what techniques others may have with dealing with this when you have the overwhelming thoughts of risks etc?