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‘Mini-brain’ models point to poorer oligodendrocyte growth in PPMS

Hey PPMSers 👋 I came across an interesting article that delves into how genetics may affect the onset and progression of MS. The article discusses a recent study that used stem cells derived from people with MS to develop cerebral organoids, also known as "mini-brains," to better understand the cellular and molecular mechanisms leading to the neurodegenerative disorder. One of the study's main findings was that patient-derived stem cells, especially those from people with primary progressive MS (PPMS), tend to be less able to grow into myelin-making cells called oligodendrocytes. These cells are responsible for repairing the myelin sheath around nerve fibers in the brain and spinal cord. The study suggests that genetic differences among people with MS, especially PPMS, might lead to lower oligodendrocyte activity, which may contribute to poorer myelin repair and increased neurodegeneration. The study is important because it provides new insights into the innate cellular dysregulation in MS and identifies p21, a protein that plays an important role in regulating cell growth and division, as a new protein of interest. The scientists hope that their organoid models will serve as a useful tool for future studies and in understanding how a person's genetic background influences MS development. This novel technology may open the path to future therapeutic approaches and a long-awaited cure for patients with MS. If you're interested in the latest medical breakthroughs, check out the full article here 👉 https://multiplesclerosisnewstoday.com/news-posts/2023/02/13/mini-brain-models-slower-oligodendrocyte-growth-ppms/ Cheers, Billy

@billyshift, thank you - that was fascinating! When I think of the amount of angst that could be mitigated with a simple genetic test I'm astounded that it isn't SOP for family medicine. Instead of chasing symptoms for years it's so simple to check a few SNPs and say "Hey, you have a higher chance of MS than most people, let's get you an MRI." Thankfully we're all able to access the tech. Unfortunately the results aren't typically distilled into easily digestible sound-bytes. Do you think the broader community would find any benefit with a 'how-to examine your own genetics' type seminar? Granted, most members already know they have MS, but it may be beneficial for those who are awaiting diagnosis.