Hi @Bettyarcher, 
I started on Tysabri in January and can honestly say I feel better than I have in years. This is my first DMT so I can't compare it to anything else. I wasn't offered Ocrevus as I had treatment for breast cancer a couple of years ago and it increases risk of recurrence, I think. Tysabri we the most effective treatment I was offered. The PML thing does keep me awake in the middle of the night sometimes especially once I found out I am JC + . I have been reassured that the chances are low and I will be regularly assessed. And I feel so much better it seems worth the of sleepless night!

Hi @Bettyarcher I was on tysabri to start with and after my second session I had a really bad reaction so they had to move me to another dmt so they  moved me to ocrevus and I’m ok with it once I’ve had it I’m just tired that’s it really and it’s every 6 months where as tysabri is every month so it depends on how many times you want to go to the hospital for the infusions

Hi,@Bettyarcher,  I was diagnosed last year in September and I had to choose between Tysabri and Ocrevus. 
I did choose Tysabri ..the monthly infusion 2h drip...and I don't regret it .. I feel great on it...
In June I'm gonna have my 7th infusion ..and I can say I'm simptomes free ..most of the times. 
I'm JCV positive,  I had the test done in full pandemic and it took almost 3 months for the results to arrive as the test it's made overseas ..as they told me ... 
Atm I have a low index .. below 1..so..🤞
You can ask your ms team if they can test you for JCV before ..to help you decide ...the result should arrive much faster now as some of the restrictions eased.

Ocrevus is an infusion every 6 months...6-8 h drip ..and I believe it lowers your immune system ..but I will let this to someone that's on Ocrevus ..as they know more than I  do😅.
Wish you all the best .

Dear @Bettyarcher,

I have been on Tysabri for 3 1/2 years now, after two bad relapses in quick succession.  The second put me in hospital for three weeks, and my neurologist told me that my MS was "rapidly advancing".  I haven't had a relapse since.  Although I switched to JC+ after about two years, the risk is well-monitored.  Now that interval dosing has decreased from 4 weeks to 6 weeks, I gather that that further lessens the risk of JCV.  The other good thing about Tysabri, particularly in these COVID times, is that one can have the COVID vaccine at any time, with no loss in effectiveness.  Sure, we have to go to hospital every six weeks instead of twice a year, but that's an inconvenience I'm well-prepared to put up with.

Best wishes,

Jon

Thank you everyone for your helpful and informative comments 🧡 i have chosen to go on Tysabri, as I do think this is the best option for me right now. Having my bloods done tomorrow and an appointment with the MS nurse on Tuesday, so its all go go go! @wjgregg @RoxanaM @ant87 @Vickyms

@bettyarcher good luck and hope everything goes well for you

@Bettyarcher, good luck and hope everything goes smoothly for you 🤞🍀.

@Bettyarcher. Glad we've helped. That's the best thing about this website, it's like chatting to friends and can really clear your head. Hope it all goes well. ☀️

I am curious as to whether you can just switch from one to the other - and back again. I also had to make this decision @Bettyarcher and I decided on Ocrevus. I now wonder if I should have chosen tysabri due to the immune system / pandemic thing.  I am also curious to know how does one actually become JCV positive. Is it something that you catch from other people?

@KateB
This link might help answer your question.
Hope it helps.
https://mstrust.org.uk/a-z/jc-virus-and-pml

@kateB I'm pretty sure there's a 'flushing out' requirement with both drugs before any switch. Given Ocrevus is a biannual infusion my guess would be the flush would need to be that long at least

I had Lemtrada but had a big relapse 2yrs after so have just changed treatment. I chose Ocrevus over Tysabri and Mavenclad and had my first dose (split 2wks apart) last month. Weigh up the treatment and pick which feels right for you x

Hey guys,
Its been a little while since I have posted on here!I hope you are all doing okay.

So, turns out the Tec isn't working for me as my recent MRI showed new lesions on my brain and spine. I have been given the option to go on either Tysabri or Ocrevus. I have been doing so much research and I'm still unsure of which DMD to choose 🙃 with Tysabri, the whole JC virus and PML does scare me slightly....any advice would be appreciated 💜💜