Last reply 2 weeks ago
Switching from Tecfidera to Ocrevus?

Hi all, I’m currently on Tecfidera and have just been told I’m eligible for Ocrevus. My MRIs since starting Tec have been mostly stable with a few very small new lesions last year but I don’t love taking the pills every day, often forget them, and then have bad flushing, and my mood is often quite low and I wonder if that has anything to do with the Tecfidera.

I’m wondering if anyone else has made the switch and how they found it? I’ve read about headaches persisting for months after the first infusion, and have also read about some people’s symptoms getting much better and others getting much worse after the first treatment. I think I do want to make the change but am a bit nervous and would love to know how anyone else has got on, or if it’s just a no-brainer to switch since it’s classed as more effective if the hospital is willing to give it to me. Thanks for your thoughts!

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2 months ago

I’m on Ocrevus and it’s never given me a headache and I don’t receive the Tylenol they usually give before the infusion. It’s made my symptoms much better, but after the first two halves I didn’t get a bit worse for a month or two. I didn’t have the flare up of symptoms after the first full dose. My MRIs showed no new lesions or disease activity.

2 months ago

@mlgilber1 thanks for replying, that sounds very positive.

2 months ago

@sarahjay I did just that in January. Such a horrible disease warrants strong drugs. I have had zero side effects. Well, perhaps a bit of Itching from time to time. Nothing like the flushing I got on Tec. Nothing at all.

I think the last few lines of your post answer your question 🙂

My second infusion is due in July. Also don’t have to constantly try to remember to take the wretched pills as close to 12h apart as poss.

Bon chance.

2 months ago

I am on ocrevus 4 months now can’t complain of headaches from it just the usual ms symptoms of crappy ms fatigue.i was on rebif 1st for 3 years then tecfidera for 1 year was still getting lesions got onto ocrevus Feb 2019 it’s got good odds for a dmd. So hope all goes well I think the changeover from other dmds takes a lot out of you it did me. Another good thing about being on ocrevus is that it’s approved for ppms as well so you won’t have to changeover dmds again. Ms is crap so keep positive and take it easy we are all in the same boat as a lot of others. Doughnut time for me now take care😋

2 weeks ago

Thank you all. I’m going to switch witht the first infusions on September, and will report back in case its helpful to others making the same decisions.

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