I am waiting for this sudden mist to burn off so I can do my walk in better visibility. In other news, my bread is getting better. Incrementally. After 3 weeks of living in one another’s pockets, Mrs S and I have been rather techy with one another this morning. To be expected. Imagine our planned walk together will be a solo affair!
Not Covid-19 related but interesting about ocrelizumab. Despite how the headline appears it is not a new trial but further data analysis of the two big trials that got the licence called OPERA1 and, rather unsurprisingly, OPERA2. The upshot is that the further analysis of these ginormous data sets has made it clear that for better evidence still further specific trials need to be run. The issue for us patients with pharma companies is that if they feel that the extremely high cost of running these trials outweighs potential gains in revenue then they are unlikely to fund them. This leaves us in the hands of people like Prof G, Prof Schmierer etc at the Blizzard Institute at Barts and other global research teams to run such trials.
Reality Bites – an interesting post about going forward and what losing our focus regarding distancing etc the Covid-19 pandemic will mean to everyone, including pwMS. https://multiple-sclerosis-research.org/2020/04/a-mscovid19-reality-check/
Here is some more work comparing the success rates of easing in gently (Escalation) with hitting MS hard and fast upon diagnosis (Induction). It is with mitotraxone as these studies take a long time to do so this started a while ago before the newer therapies were in widespread use. It is still interesting as even with this slightly cnstrained viewpoint it is looking less likely that the default position should be escalate. Obviously there are different circumstances for everyone, this is contributing to the ongoing debate about the initiation approaches. https://multiple-sclerosis-research.org/2020/04/induction-verse-escalation/ and for the actual paper with no commentary though you need library access to read the entire thing and quite a few people here do http://tiny.cc/IvsE
It seems @vixen is not so keen on bbq brisket 😉 It wasn’t a meat vs veggies thing. I eat more veggie than meat these days for cost and health reasons. If I am going to eat a slice of signature meat before I kark it I want that brisket though and also some really good Kobe beef.
However, to go with them I’d need a very well cooked aubergine parmigiana like so https://www.youtube.com/watch?v=rq1EUwiLa6M
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