Last reply 1 year ago
CIS and symptoms?

HI everyone,
i have not been posting much lately on the site, as I was busy with life and a number of MRIs.I have been under supervision of a neurologist as I have 6 non active lesions in the brain since end of 2016. After 3 different MRI scans since then there is no new activity and no spine lesions /o.bands. My neurologist tells me I have clinically isolated syndrome – CIS. (last MRI done 2 weeks ago and nothing has changed)
Subjectively I feel like my legs ( spasticity/tingling) seems to be more frequent than lets say 1 year ago… (its mild, but I feel the frequency increased) so my question is, would a CIS diagnosis have continued residual symptoms? would this be something to expect?
i have hyper-hydrosis ( frequent sweating), overactive bladder, and I run out of energy sooner than I normally think I should – all these developed gradually), but otherwise nothing else, no balance issues or walking difficulties. Somethimes I am thinking if this is not early PPMS.. but my neuro does not think so, so I am trying to think positively.

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1 year ago

From what my neuro has told me — PPMS patients tend to have at least SOME scarring (lesion/s) in their spinal cord, so I wouldn’t worry that much about it, at least for now. Enjoy being more or less symptom free 😉

1 year ago

@matus82 , Clinically Isolated Syndrome (CIS) is basically considered to be a single relapse. That is unless you can recall separate unexplained medical issues.

So, there can still be some scarring on your Central Nervous System (CNS) causing residual systems. There’s some more details about CIS here:-

It would be worthwhile for you now to keep a symptom diary (, so that you can recall all events when you next see your Neuro.

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