#multip - Shift.ms

Does Multiple Sclerosis make you cranky?

I asked artificial intelligence because I am so cranky I can barely stand being around myself. Short answer: yes, it can. But not in a simple “bad mood” way. Multiple sclerosis (MS) is a neurological disease that affects the central nervous system. When brain regions involved in mood regulation ar...

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@DaniRam89

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I was hoping to start Ocrevus, but I can’t afford it. I was diagnosed with multiple sclerosis in October started off with me going blind thank the Lord I got my vision back, but I can barely walk and numbness and tingling in my hands I feel like a completely different person, but I downloaded this app and made an account to hopefully get some insight on affordable medication that may help. I hope you all are doing well. God bless you all.

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@JoshuaOct2024

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Please comment on your treatment for Primary Progressive Multiple Sclerosis. Trying to understand what options are out their and the success of them.

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@GabrielMendoza

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Not a question just got diagnosed with Relapsing Multiple Sclerosis

I’m still trying to wrap around my finger everything I was once able to do now I’m in grieving stages and man this has sucks so bad. I went from doing jiujitsu to now keeping away from doing things because now I have no energy.

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@Tia

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Saw this and wanted to share : A microscopic discovery may quietly change how multiple sclerosis drugs are designed and why their side effects happen at all.For years, doctors have relied on immune-modulating drugs to slow multiple sclerosis (MS), even though many come with troubling side effects affecting the heart, lungs, or nervous system. Now, scientists from Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center have uncovered why some of those side effects occur and how future drugs could avoid them.Using ultra-high-resolution cryo-electron microscopy, researchers mapped the exact molecular structure of siponimod, a next-generation MS drug, as it binds to its immune target: the S1P1 receptor. This receptor acts like a gatekeeper, controlling whether aggressive immune cells escape lymph nodes and attack nerve insulation in the brain and spinal cord.The breakthrough? Scientists discovered precisely which parts of the drug help it hit the right receptor and which subtle features cause it to accidentally bind to similar receptors linked to abnormal heart rhythms and other side effects. With this structural “blueprint,” future MS drugs could be engineered to lock onto the correct target more tightly while avoiding the rest.Even more intriguing, the study reveals how nearly identical natural lipids can behave completely differently inside the body, shaping immune, brain, and lung function. That insight may ripple beyond MS, influencing treatments for lupus, psoriasis, inflammatory bowel disease and even lung disease.If medicines could be redesigned at the molecular level to spare the rest of the body, would you accept stronger immune control with fewer side effects?

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@Mytinyspotted

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Multiple sclerosis and pregnancy

I was sooooooo active pre, during pregnancy now post I’m exhausted badly wanting to move nor motivated but I have to do something 😮‍💨baby girls eleven months time to take back my energy lifestyle

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@lagunasm545

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