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Plegridy or continue with Avonex

Hello, I have been on Avonex for 5 years and have got used to the flu like symptoms I feel for 24-36 hours. However, I have really struggled for over a year to inject myself and both thumbs are now weak/ damaged. Sometimes it can take 10 minutes of hard pressing (and serious sweating!) to inject. I had a review with my MS consultant who has suggested i move to Plegridy. I have been reading some of the comments about Plegridy and it sounds pretty grim. They weren't offering anything else. Would welcome any thoughts. Thanks, Rich

Hi @RichJ . Injecting sounds super stressful. I was finding it hard to inject myself weekly. Especially, as I was finding the auto injector really difficult to use. I was also offered plegridy. I opted to ask for another drug. Luckily I got what I wanted. Although, I waited 9 months with no treatment. That was really hard. I guess treatment choices are difficult to make. The escalation model has now been shown to be less effective than the de escalation model. Charities can be really helpful with loads of information about treatment route, frequency, side effects and efficacy. I don’t feel the NHS give this information 😢. NICE also give guidance to clinicians. Hope this helps.


Thanks Clary. I hope the drug you are using is bearable and working. Appreciate your prompt response and wish you all the best