I was on Copaxone and then Tysabri for several years. I wasn’t having any new lesions and couldn’t say that Tysabri was making me “feel better” so decided to go off it. I was off all DMTsfor 2 years. Only recently I started having tremors in my hands, which is truly the first utterly NEW symptom that I’ve experienced since 2006. So I decided that I had best go back on Tysabri. I will see if my doctor recommends a new MRI and am curious to see if there are any new spots. I will say, none of my past DMT medications made me feel worse. I just couldn’t discern whether it was helping. I guess we have to do what we feel is right for us based on our circumstances at the time. Glad to hear that you are stable in any event.

Yes, me too. Copaxone. Then Aubagio, then ocrevus. Copaxone made me floated and caused that horrible IPIRs, with aubagio my hair fell out. (Well, not all) and kept showing leasions. Ocrevus caused me having the flu every month or so. 1,5 years on nothing. 2 relapses, but i will not go back. The cure is worse than the ailment! Even neuro thought so. And we will cross that bridge... etc. Just do what makes you feel comfortable. But always keep listening to good-old-neuro as well.