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Starting Tysabri on Monday

Hi, Had MS for approx 16yrs. I've been on Avonex and over the past 4yrs Gilenya. Unfortunately both didn't work for me and my last MRI showed my MS was still highly active and had acquired a number of new lesions despite being on Gilenya. Lemtrada was discussed but apparently the change from Gilenya to Lemtrada has not gone so well for some patients so it was decided I'm going to start tysabri and that will be on Monday at the Sunderland a Royal hospital. Has anyone else gone from Gilenya to tysabri? Any advice or tips you can give me? Anyone on tysabri at Sunderland royal or nearby? Eager to get it started but a little nervous too as I'm JC positive. Thanks!