I was on Copaxone for about 5 years, and I really liked it because I didn't notice any side effects except for injection site reactions. (Which were a bit unpleasant.) I would have liked to have stayed on it, but I had to switch to Avonex as my injection sites were finally worn out, with quite a lot of skin atrophy. I've put up with Avonex now for 7 years, but in my case the flu-like symptoms have been a real pain. I'm about to switch to Plegridy, in January. Plegridy is a newer formulation of Avonex, which was developed to inject every two weeks, rather than every week. The side-effects seem to vary greatly from person to person, so you may be lucky and get away with a fortnightly Plegridy injection that you can just forget about in between. Of course, if you chose one that you really didn't get on with, it would always be possible to switch again down the line.

@julesds1977 , it is well worthwhile reading up on all the available DMTs, as the two suggested for you are entry-level, first line therapies. There are better, more effective treatments now available. The strategy of starting with the least effective treatment, upgrading as you acquire more disability is now outdated. The "hit it hard and fast", with the most effective treatments, is the latest strategy. Here's an introduction to DMTs :- https://support.mstrust.org.uk/file/store-pdfs/Disease-modifying-drugs-WEB.pdf With a more extensive read here :- https://support.mstrust.org.uk/file/DMD-Book-Final-WEB.pdf With a handy tool to help you decide here :- https://www.mstrust.org.uk/about-ms/ms-treatments/ms-decisions-aid