Hi Emmac1984, Welcome. I’ve had 4 rounds of Ocrevus so far and I am one of the ‘lucky’ ones who has an infusion reaction to it, including palpitations. However this is over come by keeping my infusion rate at a maximum of 90ml/hr (s l o w!) while simultaneously being given ALL the antihistamines. Before, during, after and for a few days after. I still get the odd pitty pat even with all the Piriton but it’s manageable. Try to keep an open mind as you may breeze through your infusion (most pretty much do from others accounts I’ve read here) and not have any cardiac symptoms at all. One thing is for sure, if you get super anxious worrying that you will, you’ll be more likely to do to get sheer adrenaline flying around your system! Easier said than done not to worry, I know. I would just say be aware if you start getting itchy during your infusion as they increase the rate (which will be done slowly with careful obs being taken) and your first infusion will be broken into 2 parts anyway to see how you go. Getting super itchy and hot is my first sign that I am reacting. Then I get an impressively dramatic rash come up, heart rate goes nuts followed by blood pressure… We don’t allow this to happen now because after 2 attempts at increasing my rate both ending the same way (see above) we now know my rate is 90 and we stick to that. It’s just means I am there aaaalll day 🙄 I really must add though that I think I am far more the exception than the rule in my response to Ocrevus. Most do just fine and even I do now that we know how to prevent all the bells and whistles going off! Wishing you the best. PPS xx