Last reply 3 months ago
Statins? Simvastatin 80mg question

Is anyone here taking Statins? Either as part of the MS-STAT trial ( https://www.nihr.ac.uk/documents/case-studies/ms-stat-impact-case-study/21482 ) or just because – of simvastatin 80mg or any other dose of atorvastatin for that matter?

I have persuaded my GP to give me atorvastatin (one of the same class of drugs) as it has – apparently – a better side effect profile than simvastatin.

I am interested t know what – if any – side effect the 80mg simvastatin dose gives commonly. Side-effects listed in data sheets seem to bear only a loose resemblance to real life as they tend to be massively over-reported because of the typical clinical trial population and the requirements – necessarily strict – for reporting on trial, which leads to anything and everything being recorded and reported with no filter.

Thanks.

Dom

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stumbler
3 months ago

@dominics , I was originally on Simvastatin 40mg. I was borderline for requiring a statin, so being aware of this research I opted to adopt it.

For the last few years, I’ve been on Atorvastatin 40mg.

No side-effects experienced, but I’m only on 40mg……


dominics
3 months ago

Thanks @stumbler .

The dose equivalence means 40mg of atorvastatin is the equivalent therapeutic effect of 80mg of simvastatin.

You are getting what is needed!


stumbler
3 months ago

@dominics , it’s not helping me………..😣

Perhaps I’ve been prescribed a placebo! 🤣🤣🤣


dominics
3 months ago

I doubt it. Atorvastatin is usually much better tolerated than Simvastatin (why I went for it). My GP wants to titrate up from 10mg as he is a cautious fellow. I need to get him to 40mg as soon as. I have sent him the trial data and the dose equivalence data so am trusting that he sees the rationale.

Anything I can do to retain cognitive function – or try to normalise the loss rate – and retain brain volume – or again to get closer to the normalised loss rate – the better.


watsoncraig
3 months ago

I am on 10mg Atorvastatin for Familial Hypercholesteremia (genetic high cholesterol), was on Simvastin about 14 years ago so can’t remember the strength but I was having weird vivid dreams so got swapped to Atorvastatin and no issues with it and my cholesterol is now less than 4 not the 7.8 it was


dominics
3 months ago

@watsoncraig I am conspiring with my doc to use the cover of high lipids and hypertension as an excuse to Rx the statin. They have a calculator on their system and, try as we might, I can’t hit the target of 10. However, I got close enough at 6.8 for them to feel comfortable about Rx the drugs. They know the real reason I want them! Win-win as they get to tick a ‘doing the right thing for an older (51) patient’ who may well be in a risk category box so better safe than sorry.

My concern is that the trial data is on a high-dose simvastatin and I don’t want to be swallowing something underpowered as there is little point. I need to get them up to Rx 40mg if it to is affect brain volume loss and cognitive function in the same way.

What you say about the dreams is consistent with what I have been told by a community pharmacists, hence the atorvastatin request.

PS: Did you receive the email I sent?


watsoncraig
3 months ago

Atleast I was not the only one to have the dreams.

I got the mail thanks


guinness
3 months ago

@dominics I was on 80mg simvastatin from 2014 after suffering a stroke and only recently changed to Atorvastatin and currently on a dose of 60mg increasing it to 80mg in the upcoming weeks I have had no side effects from either drug


dominics
3 months ago

@guinness thank you for that.


d1zzy
3 months ago

Hi @dominics I am on 80mg Simvastatin and have no idea whether there is any benefit. My neuro suggested it, and in the absence of any other treatment suggestions, I was glad to give it a go. I am getting the vivid dreams, but they have been more entertaining than problematic. I haven’t been so good over the last couple of weeks so am thinking of trying to bring my annual appointment forward.


dominics
3 months ago

Going on the trial data there is definite benefit. Not something you feel per-se.

The technical advice regarding dose equivalence is 40mg atorvastatin = 80 mg simvastatin. Perhaps all your Neuro to give that a whirl as it is generally better tolerated?

You can also get your GP to do it as now you are on 80mg simvastatin the precedent has been established so they may switch you based on their far greater experience of using statins.

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