Hi there, Just looking for some other peoples experiences but I know everyone's is different. I was diagnosed in April 2020 with RRMS - they thought I suffered a stroke but after an MRI they suspected MS. I was waiting for the neuro appointment and could not cope with the fatigue in my legs and a loss of balance when walking. I was admitted to hospital, lumbar puncture done and started a course of steroids for 3 days and then went home (Late April 2020) In October, I will be having my 6th infusion of Tysabri but I feel like it is not working. I am doing a self build and continued working on it from late May. The fatigue has never left, I get terrible nerve pain in the soles of my feet, struggle with my fingers and arms after a days work. I am not one to sit around - never have been. In August I was advised to step back from everything from my GP. All I did for 14 days was go to work (office work) but the fatigue has still not left!!! I feel like the Tysabri is not working and I am getting progressively worse. Neuro will not bring my appointment forward either - I am extremely frustrated at the moment - limiting myself to a days work on a Saturday at the house. Going out of my mind! Has anyone on here, that was diagnosed with RRMS progressed quickly to SPMS or PPMS that quickly! Genuinely living in fear and half thinking of making the house more accessible while I can. So unsure of everything at the moment :( TIA T.J