Last reply 3 weeks ago
Brabio reactions

I have been injecting Brabio for about 3 months and each injection site is bruised and in agony for about a week after the injection.

I rotate sites for each injection, but by the time the pain and bruise has gone away, I am back there again and it all starts again. Because of this I have about 4 places on me in pain at any one time. Any advise how to make the after effects less severe?

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stumbler
5 months ago

@dibs , Brabio is the generic version of Glatiramer Acetate (Copaxone).

You should be considering that each of the seven injection sites can be divided up into several sub-areas. Injection depth is also important.

The following might provide some advice for you :-

https://www.copaxone.com/globalassets/copaxone/injection-sites.pdf

And this might be a handy tool for you :-

https://www.copaxone.com/injection-assistance/itracker-app


dibs
5 months ago

@stumbler, thank you – very helpful. I will also have a play with the depth dial on the auto injector to see which works best at each site. Some are less painful than others, so guess it is just going to be a bit of trial and error at first…


stumbler
5 months ago

@dibs , this is probably a better place for you to start, it covers suggested needle depths :-

https://www.copaxone.com/injection-assistance/how-to-inject


itsmewithms
5 months ago

@dibs You listed Copaxone as your DMT…did you use that previously without issue or the same issues? That would be an important detail to discuss with your Neuro. They likely use different fillers or other ingredients you may react to.

I used Copaxone for 11 years but stopped about 5 years ago when I switched to Rebif. I was having increasing lesions with no real obvious attacks so when I moved to a new Neuro he switched me pretty quickly and has now moved me to Ocrevus. I also had kind of dimply/crepy skin at my favorite injection site (inner thigh) and the Dr didn’t like that at all. The injection sites suggested on my upper thigh and back of arm really didn’t work for me so the nurseline said I just needed to inject subcutaneous, under the skin into a fat layer so to find my best spots and rotate them. They also suggested a warm compress (washcloth with warm water wrung out) if there was a sting and rubbing the area before and after. I didn’t have as much of an immediate site reaction with Copaxone as I had with Rebif but after a Copaxone injection I would have the enduring bee sting type of bump that I never got with Rebif.

I don’t know how aggressive your MS is or why Copaxone/Brabio was chosen as your DMT. It was also my first DMT but there weren’t many options 15 years ago 😉 There are more options today with better efficacy. If this one isn’t working I’d talk with your Neuro. I have seen a lot of discussion of Brabio in this forum. If you put it in the magnifying glass/search in the upper left you will find previous discussions on it. This DMT is often chosen as a “starter DMT” for neuros who follow the “escalation” theory of treatment. If you check out videos on Dr Boster’s site he will refer to them as “old school” while he favors a more aggressive treatment regimen- the “new school”

Still a Role for Copaxone today?-


hope33
5 months ago

Just wondered if you would consider manually injecting. This sometimes causes less issues with burning, bruising and bumps.


dibs
5 months ago

Thank you @itsmewithms this is the first DMT I have tried as I was only recently diagnosed and the one most suitable at the moment as I am planning for a baby. I will speak to my neuro about it all as it was fine the first few weeks but has become more painful each time.


dibs
5 months ago

@hope33 I will give manually injecting a try and see if that helps. Thank you


lilypalooza
2 months ago

@dibs have you continued to auto inject and has it got any better? I was recently diagnosed and also put on Brabio…8 injections down and absolutely fine for the first 6 but the last two have bruised quite badly. I’m not keen on the other areas for injecting so have been sticking to my thighs but am thinking this could become problem? Like you I’m on Brabio as planning for a second child so other DMTs not an option right now…


dibs
2 months ago

@lilypalooza I carried on auto injecting and I played with the depth at each site plus a warm compress after and think I’ve cracked it! Some places get itchy afterwards but no more pain or bruises.


lilypalooza
2 months ago

@dibs that’s good to hear! I shall do the same, thanks x


dibs
2 months ago

@lilypalooza good luck! Hope you find a way for it to work for you x


pikilily
2 months ago

Hiya, I have found that taking an antihistamine has eradicated the itchy and discomfort. I am now on the 40mg 3x week reigime and I don’t get any reactions at all…well occasionally a mild ache for 5 mins. I cant complain about that! 😁😁


dominics
2 months ago

@dibs I had v similar issues to you. After injecting beta-interferon for several years I moved to it. I don’t give up to easily and stuck it for 6 months. Looked like I had been in a shotgun accident towards the end.

Given it is one of the least effective medications have you considered along your nurse about alternatives? Assuming that you are try not to conceive.


dibs
2 months ago

@dominics I think I’ve nailed it now and no more bruises. Just a bit itchy sometimes. This is the only choice for DMT for me at the moment as planning for a baby in the v near future…


dibs
2 months ago

Thanks @pikilily. I hadn’t thought about antihistamines. Will give this a go as well!


dominics
2 months ago

@dibs – the good thing about pregnancy is that it has beneficial effects on MS. I know one (maybe more) of the shift.ms team is putting together more on this.

Back to Glatiramer Acetate though. I used cool packs post-injection, if memory serves I tried Bio-oil but it was so long ago – 8-10y – my memory is not entirely good.

We were developing a plan to see what worked best. The ongoing issue was little hard lumps that were reddish after the surrounding colour had returned. They were persistent.

We were going to try warming the area first and then cooling it first. Essentially a process of elimination.

There was ibuprofen and paracetamol options.

The next phase was extending the sites and keeping a pretty detailed visual record.

Best of luck. Nicer problem to have than many that are rearing thier heads these days!


highlander
3 weeks ago

@lilypalooza
This page might give you a little advice.


lilypalooza
3 weeks ago

@highlander thanks – have already read it because of the itching! No shivers though…maybe I’m just weird! 😂

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