Diagnosed in 2019, I've now been on plegridy for close to 3 months and although I've had some side effects they were nothing in comparison to the horror stories I read online. The 1st time I felt like I had been beaten up, and at one point I had some problems with breathlessness but that's it. When I self inject, its very simple and there's never anything more than site reactions (which don't hurt at all) or at worst a small bit of blood if I screw up where the needle hits. It's a lot less interesting, writing about something that isn't a horror story but when I was looking for reviews of plegridy before it would have helped me to have someone say that it can be fine. Because it can be fine, it has become just another thing I take and all anxiety of self injection has passed, the actual process of administration is incredibly easy and tbh getting on, getting used to and then maintaining the dosing has had little to no impact on the way I live my life.