Hiya, I've been on plegridy for around 6 years now, and I'm really struggling with it now. I'm ill for about 3 days every other week, and I'm having one of my most debilitating MS episodes so far. I'm thinking of a switch, what does anyone think of Tysabri or Gileniya? I don't know if I'll be offered either, but I have a meeting with my consultant tomorrow :)