Problem is no one knows if it will work for you individually and anyone who says they do is speaking from anecdote or what are limited research studies. 1. If you have failed a high efficacy drug like Tysabri (as in your profile), HSCT (or an immune reconstitutor like lemtrada) is is probably your best option for slowing or pausing progression. 2. If you are rapidly progressing up the disability scales EDSS wise, HSCT is probably best option. 3. It works best for RRMS rather than progressive. It may work better the earlier you get it. 4. It may not work for you, or the effects may not last more than 5 years or less. You may be the rare person for whom it works well and for longer! 5. It carries significant risk (tho not as much as it used to), also involves time off work / away from family and modification of your life for up to a year. 6. If you don’t get it when you can on the NHS, then you may pay 50-90 grand for it privately and later in your life when it’s less likely to be effective. If neither 1 or 2 are true, then it may not be best option but you’ll have to weigh up 3 and 5 as well. What does your neuro think?

@mellowmedusa My neuro is the one who has suggested / backed it. And 3 & 5 are in a good place. It’s more just the word chemo and a year of change and discomfort. But as you said hopefully for 5 years or more of improvedness