@KateB

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KateB

Ocrevus and covid vaccine

I am really interested in hearing from anyone on Ocrevus who has had the covid vaccine, as I keep being told different things from my health profresionals! Has anyone actually caught covid whilst on Ocrevus? Or been exposed to it?

Nicky13

@Nicky13

Hi Kate....do you not want the vaccine?

jamoranto

@jamoranto

Hi Kate had my ocrevus done feb 24/2021 Had my COVID vaccine done April 21/2021 I feel great about both hope you feel the same. Best Jorge

jamoranto

@jamoranto

Both were set up by my Neurologist.

Pati

@Pati

Hi Kate. Had my first Ocrevus infusion last year in October and my jab in feb. Delaying my second infusion to get the second jab and leaving a 4 week gap in between. Best Patricia

KateB

@KateB

@Pati @jamoranto and @Nicky 13 thanks for your replies. Yes I think I do want the vaccine Nicky 13, just need to make sure that it's not completely pointless! I am lucky in that I am in the South West where there is not too much COVID so I am living my life fairly normally at the moment, I have no intention of going on holiday abroad, but the time will come when I might want to get on a plane, or go to a party (if anyone can remember what one of those is) I am really not sure if the antibodies will get killed as soon as we have our next infusions...

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Smithm

@Smithm

I've had both my vaccine doses (Pfizer). I was told, have the first dose at least twelve weeks after my last infusion and second dose at least four weeks before my next infusion. The hospital were very accommodating saying I could delay the next infusion if I needed, but the timings of the doses have fitted OK. As far as I know, it won't kill off any antibodies you manage to create which will be reduced because of ocrevus, but it will kill off the B cells that create antibodies. I would think the vaccine would still trigger memory t cell and cellular response that Ocrevus won't touch (from what I understand - I'm no expert?!)...

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Pati

@Pati

Yes I’m also anxious about that. Don’t think I’ll be travelling abroad this year. But as @Smithm said I think we do create some antibodies that shouldn’t be affected by the next day infusion 🤞

DominicS

@DominicS

Prof G asked me to write this for the Barts Blog the other day. It may help. https://multiple-sclerosis-research.org/2021/04/guest-post-from-an-ocrelizumaber/

DominicS

@DominicS

The upshot is no B cell response after being on Ocrelizumab. However, there has been a study released last week in the US (biorx preprint server) showing that the vaccine generates a T cell response. This is good for us as T cells are unaffected by the ocrelizumab. What is not clear yet is whether or not the immune response from T cells alone is equivalent to a ‘normal’ subject. It doesn’t mean it isn’t, it means that right now there is no way of being clear as to how effective it is. I have put up two further videos about this (there are two in the Barts post) on theMSguide.com

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KateB

@KateB

@DominicS thanks as ever for your help. I just read your blog. I don't think we will really know until people on Ocrevus actually catch it. I also watched your interview with your daughter, she is adorable and very eloquent! @Smithm thanks for your response, did you choose to have Pfizer over AZ?

Smithm

@Smithm

I didn't choose. It was just the one given. To be honest I would have been happy with either! I had it at a vaccination centre next to a hospital so think it's just easier for them to have stored the Pfizer one there. The blog post was a good read. You'd have to imagine there would be some vaccine response and at least to some degree, it'll be better than nothing, priming what's left of the immune system that this virus actually exists.

Tanya_Trenholm

@Tanya_Trenholm

@DominicS read your fantastic post on Barts blog and watched the videos on your MSGuide. I would be interested to know what route you took to get your antibodies tested. This hasn't been offered to me, and I wouldn't know who to ask about this. There was no joined up approach between my neuro, MS team and GP/vaccination centre. I was not proactively contacted about when to have the vaccine, nor was my GP. It was all left up to me to chase them to ask about the timing. As luck would have it, I was offered my first vaccine (by the GP-led vaccination centre) about 15 weeks after my last infusion and then managed to organise my second vaccine 5 weeks later directly through the vaccination centre. I am now having all the same questions running through my mind about switching but it would first be good to know whether I have had an immune response from the vaccines I've had...

Becky_Schaar

@Becky_Schaar

I've had both, and I'm doing great!

MarkC73

@MarkC73

I’m booked for my jabs soon and I’m sort of looking forward to that. Had my 2nd ocrevus 4 weeks ago. Brand new at this so thanks for the info here everyone 😊

Kate_The_Imp

@Kate_The_Imp

Hi, Didn't get poked yet but I am on Ocrevus. Everybody around me got the virus in the past few weeks but me 🤷‍♀️