I am not a doctor, but unless you have heart problems then I think you should be able to take it at night. I take Gilenya and it does not make me sleepy at all - are you sure it is not something else? Good luck

Hi @kimcarlson I am surprised your doc is worried that gilenya may "make your heart stop". All it can do is put your heart into a temporary AV block (basically a funny rhythm), that only happens when you start monitoring (hence first dose in hospital). Yes this can be dangerous, thus the monitoring. But it is temporary. I did have this happen to me, Heart rate dropped to 45 (from 80) (lucky me, I seem to be a shit-magnet at the moment, but that is another thread! Ha!), but it only happened with this first dose. I had the second dose monitored - it was fine. I also found gilenya makes me tired. From the people I talk to, I think this happens to about a third of us. I am now taking it at night. I started taking it in the morning (because this was when it was given at the hospital), but a couple of weeks later (after emails with my Neuro) I started taking it an hour later each day. Took about a fortnight, but I now take it just before I go to bed (hence, if it makes me tired, all well and good). I have had no heart issues since the first dose, and have now been on it 3 and a half months. Good luck! I hope you are able to make it work for you! If changing the times does not help - could this be a MS fatigue issue? :-) Jas