I was just watching one of the MS Reporters interviews (thanks for those!) and was surprised to hear the link between brain volume loss/atrophy and progression described in such simple terms. I started out thinking of it in the same way, then read some things that made me think that was wrong, now seeing the video...I'm misunderstanding something, somewhere! The first thing I'm trying to sort out: Is it true that relapse reduction - and therefore the use of DMTs - has proven to have no, or little, positive effect on long term progression? Or do the limitations of the trials so far mean there's not enough proof of a positive effect? Or is the positive effect accepted and the issue therefore with trying to measure it with any accuracy? And then: Brain atrophy is a measure of degeneration, right? Progression is caused by degeneration? So, treatments that bring atrophy closer to the "normal" range should have a significant effect on progression? Is all that just plain wrong, or an over-simplification, or are we hoping that will be the case and at the wait-for-some-solid-evidence stage? Oh look, I made a game of true or false! Hoping someone might play along and help me out :)