I have (fortunately) not had to take Solumedrol for years (thank you, Tysabri). I have some progression that neuro prescribed SM for, and after one infusion remember that I always get a fairly significant increase in all my old, partially resolved symptoms. They improve after the SM infusions end, but it is an, uh, interesting way to take inventory, and yet another reason to hate SM. Anyone else notice this? More curious than anything else.