I think personally that ocrevus is one of the best medication, but during winter time my toe and my fingers get freezed easily . before I don’t have that symptoms. when I were gloves , I am fine outside . but now I’m not. when you look at the information document they will give you, you will find also all side effects on it.

Serious Side Effects Tell your nurse and/or doctor straight away or go to Emergency if you notice any of the following serious side effects: • yellowing of your skin or the whites of your eyes, darker urine than normal or unexplained nausea and vomiting - these may be signs of a liver problem and you will need a blood test  infection - this may include flu (fever or flulike symptoms); sinus or throat infection; urine infection (urinary tract infection or cystitis); infection of the airways or lungs (bronchitis or pneumonia); diarrhoea or being sick (signs of gastroenteritis); cold sores (oral herpes); tooth infection; laryngitis or fungal foot infection, or shingles (zoster)  Pancreatitis: severe pain in upper abdominal area which may spread to back, nausea, vomiting, fever  Severe skin reactions: any combination of itchy skin rash, redness, blistering, or peeling of the skin and/or the inside of the lips, eyes, mouth, nasal passages, or genitals