Yes, for certain. For example, I’ve had a strong headache for the past day or so —not just a passing headache. Maybe I have a bug or virus. Anyway, my fatigue and pain in my arms and legs has been more pronounced the last few days. So I know my body must be fighting off something. Thankfully, I will say that I’ve never noticed any surges in symptoms surrounding my Tysabri infusion. I can’t say that the treatment makes me feel “better”, but it certainly doesn’t make me feel worse.