The crap gap” with CD20 therapies is definitely a thing for a lot of people. With the infusion versions like Ocrevus the dose is bigger and more spread out, so people often feel rougher as they get closer to infusion time. With Kesimpta it’s smaller regular doses, so it can feel a bit different. I found if I delayed taking it, the fatigue would creep in heavier, but once I’d had the injection, within a few hours I’d often feel more “normal” again… like the system had topped up the Super Saiyan juice 😅 That initial loading phase can hit quite hard though. Your immune system is basically being introduced to a heavyweight therapy at speed. For me, the first few doses were the roughest and then things gradually tapered off and became much easier to tolerate over time