I asked this of Grok and this was the answer it provided: Yes, people with multiple sclerosis (MS) can be more susceptible to intense anger, irritability, or emotional outbursts—including in response to sounds like a baby or child crying—due to several neurological and sensory changes caused by the disease. This isn’t universal (MS affects everyone differently), but it’s a recognized pattern for many. Pseudobulbar Affect (PBA) and Emotional Dyscontrol A significant number of people with MS experience pseudobulbar affect (also called pathological laughing and crying or emotional lability). This involves sudden, involuntary, and often exaggerated emotional expressions—crying, laughing, or outbursts of anger/frustration—that don’t necessarily match the person’s actual feelings or the situation’s intensity.  • PBA affects up to about 10-46% of MS patients, depending on the study and population. • Episodes can be triggered by minor stimuli (or none at all) and feel uncontrollable. Sources specifically note that some people with PBA have excessive anger or frustration outbursts. • A baby’s cry could act as a minor emotional or sensory cue that disproportionately escalates into rage or irritability because of disrupted brain pathways (involving areas like the corticobulbar tracts that normally regulate emotional expression). This is distinct from your normal mood—it’s more like a neurological “short circuit” from demyelination in the brain. Increased Trait Anger and Irritability in MS MS is independently linked to higher levels of trait anger (a general predisposition to feel anger more intensely or frequently) and state anger, even after accounting for depression or anxiety. This stems from brain lesions affecting emotional regulation areas.  Everyday frustrations (including uncontrollable sounds) can therefore hit harder or escalate faster in some MS patients. Sensory Overload and Sound Sensitivity Many with MS report heightened sensitivity to noise, including high-pitched or repetitive sounds like children screeching or crying. This can manifest as: • Hyperacusis — ordinary sounds feel painfully loud or overwhelming. • General sensory overload — leading to irritability, jumpiness, stress, or feeling “on edge.” Patient accounts describe crowds, loud environments, or kids making noise as triggers for agitation or needing to escape. A baby’s cry—acoustically designed to be urgent and hard to ignore—could easily overload a demyelinated nervous system, amplifying the primal anger response most people feel to some degree.  Stress from the cry can also potentially worsen other MS symptoms (fatigue, pain, etc.), creating a feedback loop of frustration. Misophonia-Like Reactions While not formally studied as “misophonia in MS” in large trials, some MS patients describe strong emotional reactions (anger, disgust) to specific sounds, and one smaller study explored misophonia frequency in MS patients. The combination of neurological damage and sensory changes could make trigger sounds more provocative.  Bottom Line and What Helps The “instant infuriation” you described in your previous question can be intensified in MS because of this mix of emotional disinhibition (PBA), baseline higher anger proneness, and sensory hypersensitivity. A crying baby or child isn’t just annoying— it can hijack an already vulnerable emotional regulation system. If this resonates with your experience (or someone you know with MS), it’s worth discussing with a neurologist. They can screen for PBA (there’s a simple questionnaire) or related issues. Treatments sometimes include medications like dextromethorphan/quinidine (Nuedexta, specifically approved for PBA), antidepressants, or strategies for sensory management. Coping tips include noise-canceling tools, early removal from triggers, stress reduction, and therapy focused on emotional regulation. This doesn’t mean every person with MS will react this way—many don’t—but the disease does raise the risk for these amplified responses. If symptoms are disruptive, professional input tailored to MS can make a real difference. I thought I was a bad person, turns out it’s been my MS all along. This makes me happy to know I’m not an evil person but sad this happens. 🤦🏻