From what I understand, they all work in a similar way to deplete B cells, and all are considered top-tier MS treatments. They all have similar side effects as well, which include increased risk of infection or irritation at injection / infusion site. Both Briumvi and Ocrevus require an infusion every six months (after initial loading) which takes a couple of hours, whereas kesimpta is a self administered injection at home once every four weeks. So if your neurologist is leaving the choice up to you, I think the biggest part of the decision is what works better for your lifestyle, infusions at the clinic twice a year, or injections at home once a month? I’m on kesimpta and I find it super easy and convenient. It’s an auto injector pen and takes all of two mins ☺️