We are a charity and rely on donations

Charity Number: 1117194 (England and Wales)

Registered Company: 06000961

Registered address:
Shift.ms, Platform, New Station Street, LS1 4JB, United Kingdom

London office:
Shift.ms, Somerset House, Strand, West Goods Entrance, London WC2R 1LA, United Kingdom

©2026 Shift.ms

@Feydream 

Last reply

Feydream

Freshly Diagnosed; DMT Advice?

Hello everyone! Just got diagnosed with RRMS 1.5 months after a hospital visist where I had (what I'd consider to be) a bad flare. Left leg and left hand were out of commission (numbness, lack of coordination) but after getting packed full of steroids at a hospital and about a month of self-directed therapy, I regained full control of the appendages The scary thing was looking back at all of the previous times related issues had sprang up and realizing it wasn't just in my head, it was real. I got an MRI done as part of the hospital visit and it feels like I'm covered brain to spine in lesions. I hate the thought of it, hate the thought of my body eating the Myelin sheaths and causing these flares, but I'm trying to keep a positive outlook moving forward on it I asked some good questions during the diagnosis, but I still need some informarion from those in the know. My doctor told me to do some research on the High Efficacy DMT and come back to him on which ones I'd like to try going forward. Do any of you have advice on which DMT I might select? I know they vary in dose frequency and how they're applied, but nothing else so far Thanks everyone!
First posted on the Shift.ms app
10
@slamminsammyms
@slamminsammyms
 

Sorry you are going through this. I get that it is hard to stomach our bodies attacking are attacking themselves—but I like to think of it as an allergy and somewhere along the line our bodies got confused. We are not so different but it does indeed suck. I am a strong believer in the “high efficacy” club—get on a good one before more damage is done. I’d look into tysabiri if you are jcv negative. Then kesimpta or Ocrevus (I’m on the latter). These two meds wernt on the market 10 yrs ago and are showing great results. Hope this helps and best of luck!

2
@Steve5
@Steve5
 

After my diagnosis I went to a couple of neurologist and got second opinions. The consensus from the group was Ocrevus was the best. It was the only one approved for PPMS as well. It also has a lower risk of PML compared to some of the other treatments. It has worked well for me. I have had no new lesions or flare ups since I started the treatment. I get the infusion every 6 months. There is a shot now available but I have no experience with that.

1