I have just completed the 3 loading doses of kesimpta with no problems ( I was shocked) but for tge last week I've had an almost constant ache in my calf muscles on each leg. Paracetamol quietens it but only takes the edge off. Has anyone else experienced this? I'm a 48 year old female it could also be perimenopause or the MS it's self!! It's so hard trying to figure out. Any advice greatly recieved, thanks.