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Personally, I don't think the evidence is strong enough yet to favour HSCT first-line over the high efficacy intravenous infusions. The STAR-MS trial will be reporting in the next few years so that might clarify things there. Or not. However... if I had failed on one high efficacy medication (I can see you have Tysabri listed on your profile) I would go for HSCT rather than trial another DMD. I would also go HSCT if my disability score was rapidly increasing. Things to consider: - It might be weeks to a month away from your family depending on where you have HSCT done. - There will be some restrictions on the things you can do / eat for 6-12 months and all your pre-existing immunity to contagious disease will be wiped out. - If you don't qualify on the NHS or lose the chance to qualify on NHS, you're looking at 80,000+ in UK or approx 60000 elsewhere (Mexico, Russia) to pay for HSCT. The AIMS uk charity can give you more info about HSCT - although be warned, they are very pro-HSCT and sometimes can be a bit OTT evangelical about it. It's not a miracle cure - but it looks like a very effective treatment in terms of stopping relapses and slowing disability progression.

Thoughts.. It's your choice. I wish everyone at least had the choice. Looking at the few studies that have somehow made it through against the wishes of the industry and some rather misguided neurologists, it's the most effective treatment along with Alemtuzemab. So I'd be going for it. Are you having it?