I carried my siponimod tablets around Barcelona in very hot weather on my 40th birthday. I saw on box not to store over 25 degrees and so since this time (4 years ago!!!) I have kept it in fridge. Today I have read that keeping opened boxes in the fridge can make the medication less effective and now I feel reaaaaaally stupid and like what I put down to expected progression is due to me not storing my tablets properly and therefore tablets not working. Does anybody know anything about this? Xx