Hello @alex_bolland. I think one thing is that Ocrevus is a relatively expensive DMT and so there is more pressure on authorities to adhere to strict guidelines. I’m not sure how old you are, but my understanding is that as a newish drug, there is relatively little data on people over a certain age. Our friend @dominics might be able to suggest, as he helped me word a letter to my sister’s neurology department regarding Ocrevus. Good luck!