I have been using Copaxone for about 5/6 years now and never auto-injected because of advice that it could cause more lumps and bruising. I have always manually injected with no major problems – yes the odd stinging which gets better and sometimes a lump which never stays for good. Every Saturday I take 3 injections out of the fridge and keep them in a draw or table by my bed ready for the next week. I heard that injecting at room temperature was better than taking straight out of the fridge and injecting at a cold temperature. Injections, I think can last a month at room temperature. I inject with the needle all the way in.