I’m not a particularly sensitive flower so may not be the best person to ask but I have had no real negative reaction to Ocrevus. That said I haven’t really had any big improvement but the main purpose is for it to prevent future lesions so it is what I was hoping for.
The only allergy I have is to penicillin and no other real health issues other than having a hip replacement a few years ago likely due to the impact of my MS gait/foot drop.
When you receive your infusion you will also receive a benedryl IV and Sol Medrol to control any reactions. You are closely monitored during the infusion and it is halted if there are any reactions. This happened in my first 1/2 dose when I developed a slight rash on my cheek. It was quickly resolved and the infusion resumed. I guess that is pretty typical and I had no reactions in the second half dose (also normal) and again no reaction to the first full dose. That is where I am now.
So 8 months into switching to Ocrevus and will be going into my first MRI since the switch soon. That will be the true test, I suppose, but mobility and cognitive impact has been stable which is really a win 😉
Just make sure they are fully aware of your history and concerns. I also had some over the counter Benedryl on hand and took it for a couple of days after the infusion. I did have some trouble sleeping and felt kind of “bouncy” after the infusion for a few days. My neuro felt this was likely due to the Sol Medrol which he will reduce a bit in my future infusions.
Good luck! If you click the Ocrevus tag at the bottom of your post you will see a lot of discussion on this DMT, it it is very effective and thus popular right now.