Last reply 4 years ago
Treatment / Remyelination Research

I have looked into information on development of treatments lately and it seems like the actual focus changes to the progressive types of ms as well as remyelination for nerve repair. It’s not only that some organizations focus on these topics, some clinical trials are at an interesting point also. I think many of you already know these, but I will post a brief summary:

BIIB033 (Anti-Lingo) for Optic Neuritis: Not MS, but it’s interesting to see if some kind of nerve repair is possible.The Phase 2 trial should be close to being completed (Estimated primary completion date August 2014)
BIIB033 (Anti-Lingo) for RRMS: For remyelination in MS. Phase 2 trial is ongoing, should be finished in 2016
GSK239512: Remyelination in MS. Phase 2 trials are completed
GNbAC1: According to the press releases this was tested on 10 patients, nine of which had primary or secondary progressive disease and the progress was stopped for 1 year. Phase 2a was completed successfully, next trial will follow in 2015
GLX1112: Seems to be a drug that is FDA – approved already and repurposed for MS. The focus is progressive MS. According the Glialogix homepage it has been tested in a phase 2 trial already.
New test methods: High-Throughput Drug screening to find already existing drugs that promote remyelination. 1000 have been screened already, the first candidate (clemastine) is in clinical trials
Clemastine Fumarate: Remyelinating drug. Participants for phase 2 trial are recruited at the moment.

It seems to me that some interesting things are happening at the moment. I would love to hear what your expectations are when it comes to new treatments and research for MS.

I think there is hope and that we will see some serious steps forward in the next years. I think that it will take some time before the new generation of ms drugs is on the market, 5-10 years at least, and they will not cure all ms symptoms (which would be nice). My expectations are slowing progression and probably some reduction of symptoms (Altough my hopes include some things more).
In addition, organizations like the progressive ms alliance raise my hopes.

So, what are your realistic expectations for actual research and the future treatments? Do you think a major change will happen? I would love to hear your opinions.

Nold

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stumbler
4 years ago

Thanks for sharing this summary of current developments.

It is encouraging that there is so much work going on that seems to be targeting damage repair.

It does bode well for the future. Perhaps not to my generation, but the generations following.


aussiekylie
4 years ago

Hi @nold thank you for posting this. I don’t quite understand it though. I’ve had optic neuritis since June this year and apart from initial recovery in first 4-6 weeks I’ve had no further recovery, so I’m quite interested in anything that could offer further recovery. Many thanks.


cameron
4 years ago

It’s important to keep up to speed with developments – if only as a reminder that we need to keep going and look after ourselves in the meantime. As I’ve been told many times:’it’ll be no good when a fancy new drug comes along if you’ve let yourself go’. Mm….


cazzzzzy
4 years ago

@nold – thanks for sharing this 🙂

It’s always nice to read the hope for us!

xxx


tabbycat
4 years ago

I should have read this before posting my depressing, self indulgent post. Thanks – maybe I dont have to say good bye to all the bits of me.

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