@May 2021: First episode of optic neuritis, diagnosed as Clinically Isolated Syndrome (CIS).May 2026: Second episode of optic neuritis, leading to a diagnosis of Relapsing-Remitting Multiple Sclerosis (RRMS).April 2026: Changed jobs, experiencing increased stress and long working hours.August 2026: Started Ocrelizumab (Ocrevus) DMT via injection.Current symptoms: Increased neuropathic pain and stiffness, along with a feeling of slight heaviness in my right arm.My concerns: Could these symptoms be related to MS activity, stress, or the effects of Ocrelizumab? How long does Ocrelizumab take to become effective, and should I be concerned about the worsening neuropathic pain and right-arm heaviness? on Shift.ms

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May 2021: First episode of optic neuritis, diagnosed as Clinically Isolated Syndrome (CIS).May 2026: Second episode of optic neuritis, leading to a diagnosis of Relapsing-Remitting Multiple Sclerosis (RRMS).April 2026: Changed jobs, experiencing increased stress and long working hours.August 2026: Started Ocrelizumab (Ocrevus) DMT via injection.Current symptoms: Increased neuropathic pain and stiffness, along with a feeling of slight heaviness in my right arm.My concerns: Could these symptoms be related to MS activity, stress, or the effects of Ocrelizumab? How long does Ocrelizumab take to become effective, and should I be concerned about the worsening neuropathic pain and right-arm heaviness?

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@RC83

My symptoms are very similar to yours. Happy to chat about managing them if you need too. My answer to your question: All 3. Plus a 4th thing being legacy MS lesions. Only way you will have 100% certainty whether new activity is causing the symptoms is to have an MRI.

9 Oct 2026 09:49