Interesting comments .. some had no progression while on staying without DMTs while some have been doing fine with them. Personally I tried no dmt route for about a year and half ... had a couple of relapses. My Neuro advised me ok 'enough of experimentation, time to get started on a DMT'. So got started on Gilenya and had no relapses since. I guess if you could handle it without a DMT with no evidence of progression (clinical and MRI), then I guess one could give no DMTs a shot. Otherwise you're running risk of accumulating damages.

I don’t know, @dominics. So I’ve been on Tecfidera for 2 years. No new lesions and no problems with the medication at all. But because slowly, slowly, there is deterioration with walking, with strength, with limitations, who will ever be able to tell me that I’m better with, or would have been better off without, DMDs? I mean, before being diagnosed 2 years ago, there are no MRIs to track how rapid the MS has been progressing. My hook, is that I place my trust in the professionals and in the statistics. But equally, I have every respect for people who decline DMDs. Thanks for posting the article, it’s great that there is so much credible stuff out there to help people make informed choices :-) PS, how’s the Ocrevus going?