I’m in a similar boat - Tecfidera for four years, and my immune system has taken a bit of a pounding. Had to go to a private neuro to get a Fampridine scrip’ (postcode lottery it appears), and he suggested Ocre-whatsit-man too. I whined about PML. He said that he likened my situation to diminishing resources in a pension pot, so that now we’d have to spend capitol. In other words: I’ve used up all my chances and the next relapse may take something I can’t afford to give. For this reason he said - treat aggressively. I wish you luck; I’ll be switching in November when I next see my NHS neuro, or to Cladribine if she refuses

Jomartin, whilst I was on Tecfidera my immune system collapsed and I contracted the JC virus, I was taken off it and had to wait a while, I was offered an alternative but declined and using CBD oil. I know sooner or later I will need something. I accept that all sufferers are different and would advise listening to the experts but at the same time look for other opinions, I am sure you will have more on here as this is a great home for advice. Good luck