I recognize some of these symptoms and as you know we all get different ones just to keep it interesting ;-0 I think of it as someone out there has a shotgun filled with myelin buckshot and shoots our brains. Sometimes they hit our spines. Everyone else either is immune or has a protective jacket so they don't get hit. This buckshot destroys what it hits. Our body hurries to the rescue and tries to do what it can. It lost the user manual and either does not have the materials needed or the training to fix the myelin. To make it worse everyone gets shot in a different place, our body only repairs some of the hits, everyone is a special unique unicorn for our Dr to try to figure out...if they have the energy, the training and if they care. We are left with a body and symptoms to try to manage and improve. We know we are all different from each other and yet somehow all the same. So- I never recognized any monthly pattern to my issues or symptoms so can't offer help there. Maybe a woman GP would help or a functional or integrative woman Dr. Managing your hormonal surges seems like it would really help. I am now menpausal so won't have to worry about that anymore! something to be thankful for! But the spasms I recognize and also that I have the accompanying spastacity. I started with Gabapentin to help with that and have switched to Gralise. Check that out and see if you think it could help. I no longer have spasms that would afflict me when sitting at my desk at work, during PT and especially annoying when trying to go to sleep. Also, of course, calcium and magnesium. sleep and stress also affect my emotions. When I am getting down I will try something fun as well such as a call to a friend that always puts me in a good mood, some short fun internet sites or even a comedy movie if time allows. Good luck from a fellow MS'r...on the same journey, just maybe another path

@itsmewithms loved how you put it. Thank you for the reply 😀 can get frustrating at times but not going to let it get the better of me!