@BillyBonza , I believe that your JCV status is determined before considering Tysabri. However, your JCV status can change from negative to positive at any time. So, it's a difficult call. All medications involve introducing something alien to your body. And that introduces risk of a reaction, which sometimes can be dangerous. But, that's the purpose of the trials prior to drug approval, to identify these risks. Then monitoring can be put into place to mitigate the risk. But, living is also a risk in its own right..... :wink:

I wouldn't say that any drug is "pushed" through trials, as there is a defined process. Risks have to be documented to avoid another thalidomide outrage! The trials process is a long and laboured period. Yes, some drugs are poison, but is that not like calling every car a potential murder weapon? Yes, it is our decision as to what we do with our body and the majority of us would like some relief from symptoms and some hope for the future. It's down to whether we want to look both ways before we cross this particular road. :wink: