Hi @mser79. I had a slight reaction half way through my first half infusion (itchy ear!!!!) Felt fine when I got home but for 4 days after I was really fatigued. Had my second half dose yesterday with no reaction and so far no fatigue. I did take antihistamine tablets for 5 days prior to my second dose, not sure whether that is why I had no reaction or has helped with the fatigue! Good luck with your infusion.